在神经保护相关临床前模型中探索有前景的次要天然酚类化合物

IF 2.7 4区医学 Q2 PHARMACOLOGY & PHARMACY

Basic & Clinical Pharmacology & Toxicology Pub Date : 2024-04-02 DOI:10.1111/bcpt.14006

Carlos Franciney Moreira Vasconcelos, Agnieszka Zofia Neugebauer, Ricardo Basto Souza

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引用次数: 0

摘要

阿尔茨海默病和帕金森病等神经退行性疾病的特点是，由于神经化学和免疫学紊乱等多因素的影响，特定神经细胞群逐渐丧失。因此，患者会出现认知、运动和行为功能障碍，导致生活质量下降。多年来，有关酚类化合物所固有的神经保护特性的研究报告层出不穷。因此，本综述将重点介绍有关酚类化合物的最新科学发现，这些酚类化合物是很有前景的神经保护分子，可用于预防神经退行性疾病。

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Exploring promising minor natural phenolic compounds in neuroprotection-related preclinical models

Neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, are characterised by the progressive loss of specific neuronal cell populations due to multifactorial factors, including neurochemical and immunological disturbances. Consequently, patients can develop cognitive, motor and behavioural dysfunctions, which lead to impairments in their quality of life. Over the years, studies have reported on the neuroprotective properties inherent in phenolic compounds. Therefore, this review highlights the most recent scientific findings regarding phenolic compounds as promising neuroprotective molecules against neurodegenerative diseases.

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来源期刊

Basic & Clinical Pharmacology & Toxicology 医学-毒理学

CiteScore

5.60

自引率

6.50%

发文量

126

审稿时长

1 months

期刊介绍： Basic & Clinical Pharmacology and Toxicology is an independent journal, publishing original scientific research in all fields of toxicology, basic and clinical pharmacology. This includes experimental animal pharmacology and toxicology and molecular (-genetic), biochemical and cellular pharmacology and toxicology. It also includes all aspects of clinical pharmacology: pharmacokinetics, pharmacodynamics, therapeutic drug monitoring, drug/drug interactions, pharmacogenetics/-genomics, pharmacoepidemiology, pharmacovigilance, pharmacoeconomics, randomized controlled clinical trials and rational pharmacotherapy. For all compounds used in the studies, the chemical constitution and composition should be known, also for natural compounds.