脑脊液 sTREM2 水平与抑郁之间的关系:阿尔茨海默病神经影像学倡议研究

IF 4.3 Q2 BUSINESS
{"title":"脑脊液 sTREM2 水平与抑郁之间的关系:阿尔茨海默病神经影像学倡议研究","authors":"","doi":"10.14283/jpad.2024.70","DOIUrl":null,"url":null,"abstract":"<h3>Abstract</h3> <span> <h3>Objective</h3> <p>Previous studies demonstrated a significant protective effect of elevated cerebrospinal fluid (CSF) sTREM2 levels on brain structure and cognitive decline. Nonetheless, the role of sTREM2 in the depression progression remains unclear. This study aimed to investigate the association between CSF sTREM2 levels and longitudinal trajectories of depression.</p> </span> <span> <h3>Methods</h3> <p>Data from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) Study were used. CSF sTREM2 levels and depression were measured using an ELISA-based assay and the Geriatric Depression Scale (GDS-15), respectively. Linear mixed-effect models were employed to assess the relationships between CSF sTREM2 levels and GDS scores.</p> </span> <span> <h3>Results</h3> <p>A total of 1,017 participants were enrolled at baseline, with a mean follow-up time of 4.65 years. Baseline CSF sTREM2 levels were negatively correlated with GDS scores (β=−0.21, P=0.022) after adjustment for age, gender, race/ethnicity, education, <em>APOE</em> ε4 carrier status, <em>TREM2</em> rare variant carrier status, marital status, smoking, and clinical cognitive status.</p> </span> <span> <h3>Conclusion</h3> <p>Our findings suggested that a higher level of CSF sTREM2 was associated with a lower risk of depression.</p> </span>","PeriodicalId":22711,"journal":{"name":"The Journal of Prevention of Alzheimer's Disease","volume":"110 1","pages":""},"PeriodicalIF":4.3000,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Association between Cerebrospinal Fluid sTREM2 Levels and Depression: The Alzheimer’s Disease Neuroimaging Initiative Study\",\"authors\":\"\",\"doi\":\"10.14283/jpad.2024.70\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<h3>Abstract</h3> <span> <h3>Objective</h3> <p>Previous studies demonstrated a significant protective effect of elevated cerebrospinal fluid (CSF) sTREM2 levels on brain structure and cognitive decline. Nonetheless, the role of sTREM2 in the depression progression remains unclear. This study aimed to investigate the association between CSF sTREM2 levels and longitudinal trajectories of depression.</p> </span> <span> <h3>Methods</h3> <p>Data from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) Study were used. CSF sTREM2 levels and depression were measured using an ELISA-based assay and the Geriatric Depression Scale (GDS-15), respectively. Linear mixed-effect models were employed to assess the relationships between CSF sTREM2 levels and GDS scores.</p> </span> <span> <h3>Results</h3> <p>A total of 1,017 participants were enrolled at baseline, with a mean follow-up time of 4.65 years. Baseline CSF sTREM2 levels were negatively correlated with GDS scores (β=−0.21, P=0.022) after adjustment for age, gender, race/ethnicity, education, <em>APOE</em> ε4 carrier status, <em>TREM2</em> rare variant carrier status, marital status, smoking, and clinical cognitive status.</p> </span> <span> <h3>Conclusion</h3> <p>Our findings suggested that a higher level of CSF sTREM2 was associated with a lower risk of depression.</p> </span>\",\"PeriodicalId\":22711,\"journal\":{\"name\":\"The Journal of Prevention of Alzheimer's Disease\",\"volume\":\"110 1\",\"pages\":\"\"},\"PeriodicalIF\":4.3000,\"publicationDate\":\"2024-04-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Journal of Prevention of Alzheimer's Disease\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.14283/jpad.2024.70\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"BUSINESS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Journal of Prevention of Alzheimer's Disease","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.14283/jpad.2024.70","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BUSINESS","Score":null,"Total":0}
引用次数: 0

摘要

摘要 目的 以前的研究表明,脑脊液(CSF)sTREM2 水平升高对大脑结构和认知能力下降有明显的保护作用。然而,sTREM2 在抑郁症进展中的作用仍不清楚。本研究旨在探讨 CSF sTREM2 水平与抑郁症纵向发展轨迹之间的关联。 方法 采用阿尔茨海默病神经影像学倡议(ADNI)研究的数据。CSF sTREM2水平和抑郁程度分别采用酶联免疫吸附测定法和老年抑郁量表(GDS-15)进行测量。采用线性混合效应模型评估 CSF sTREM2 水平与 GDS 评分之间的关系。 结果 共有 1,017 人参与了基线研究,平均随访时间为 4.65 年。在对年龄、性别、种族/民族、教育程度、APOE ε4携带者状态、TREM2罕见变异携带者状态、婚姻状况、吸烟和临床认知状态进行调整后,基线CSF sTREM2水平与GDS评分呈负相关(β=-0.21,P=0.022)。 结论 我们的研究结果表明,CSF sTREM2水平越高,患抑郁症的风险越低。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Association between Cerebrospinal Fluid sTREM2 Levels and Depression: The Alzheimer’s Disease Neuroimaging Initiative Study

Abstract

Objective

Previous studies demonstrated a significant protective effect of elevated cerebrospinal fluid (CSF) sTREM2 levels on brain structure and cognitive decline. Nonetheless, the role of sTREM2 in the depression progression remains unclear. This study aimed to investigate the association between CSF sTREM2 levels and longitudinal trajectories of depression.

Methods

Data from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) Study were used. CSF sTREM2 levels and depression were measured using an ELISA-based assay and the Geriatric Depression Scale (GDS-15), respectively. Linear mixed-effect models were employed to assess the relationships between CSF sTREM2 levels and GDS scores.

Results

A total of 1,017 participants were enrolled at baseline, with a mean follow-up time of 4.65 years. Baseline CSF sTREM2 levels were negatively correlated with GDS scores (β=−0.21, P=0.022) after adjustment for age, gender, race/ethnicity, education, APOE ε4 carrier status, TREM2 rare variant carrier status, marital status, smoking, and clinical cognitive status.

Conclusion

Our findings suggested that a higher level of CSF sTREM2 was associated with a lower risk of depression.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
The Journal of Prevention of Alzheimer's Disease
The Journal of Prevention of Alzheimer's Disease Medicine-Psychiatry and Mental Health
CiteScore
9.20
自引率
0.00%
发文量
0
期刊介绍: The JPAD Journal of Prevention of Alzheimer’Disease will publish reviews, original research articles and short reports to improve our knowledge in the field of Alzheimer prevention including: neurosciences, biomarkers, imaging, epidemiology, public health, physical cognitive exercise, nutrition, risk and protective factors, drug development, trials design, and heath economic outcomes.JPAD will publish also the meeting abstracts from Clinical Trial on Alzheimer Disease (CTAD) and will be distributed both in paper and online version worldwide.We hope that JPAD with your contribution will play a role in the development of Alzheimer prevention.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信