脑脊液 sTREM2 水平与抑郁之间的关系：阿尔茨海默病神经影像学倡议研究

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The Journal of Prevention of Alzheimer's Disease Pub Date : 2024-04-02 DOI:10.14283/jpad.2024.70

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引用次数: 0

摘要

摘要目的以前的研究表明，脑脊液（CSF）sTREM2 水平升高对大脑结构和认知能力下降有明显的保护作用。然而，sTREM2 在抑郁症进展中的作用仍不清楚。本研究旨在探讨 CSF sTREM2 水平与抑郁症纵向发展轨迹之间的关联。方法采用阿尔茨海默病神经影像学倡议（ADNI）研究的数据。CSF sTREM2水平和抑郁程度分别采用酶联免疫吸附测定法和老年抑郁量表（GDS-15）进行测量。采用线性混合效应模型评估 CSF sTREM2 水平与 GDS 评分之间的关系。结果共有 1,017 人参与了基线研究，平均随访时间为 4.65 年。在对年龄、性别、种族/民族、教育程度、APOE ε4携带者状态、TREM2罕见变异携带者状态、婚姻状况、吸烟和临床认知状态进行调整后，基线CSF sTREM2水平与GDS评分呈负相关（β=-0.21，P=0.022）。结论我们的研究结果表明，CSF sTREM2水平越高，患抑郁症的风险越低。

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Association between Cerebrospinal Fluid sTREM2 Levels and Depression: The Alzheimer’s Disease Neuroimaging Initiative Study

Abstract

Objective

Previous studies demonstrated a significant protective effect of elevated cerebrospinal fluid (CSF) sTREM2 levels on brain structure and cognitive decline. Nonetheless, the role of sTREM2 in the depression progression remains unclear. This study aimed to investigate the association between CSF sTREM2 levels and longitudinal trajectories of depression.

Methods

Data from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) Study were used. CSF sTREM2 levels and depression were measured using an ELISA-based assay and the Geriatric Depression Scale (GDS-15), respectively. Linear mixed-effect models were employed to assess the relationships between CSF sTREM2 levels and GDS scores.

Results

A total of 1,017 participants were enrolled at baseline, with a mean follow-up time of 4.65 years. Baseline CSF sTREM2 levels were negatively correlated with GDS scores (β=−0.21, P=0.022) after adjustment for age, gender, race/ethnicity, education, APOE ε4 carrier status, TREM2 rare variant carrier status, marital status, smoking, and clinical cognitive status.

Conclusion

Our findings suggested that a higher level of CSF sTREM2 was associated with a lower risk of depression.

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来源期刊

The Journal of Prevention of Alzheimer's Disease Medicine-Psychiatry and Mental Health

CiteScore

9.20

自引率

0.00%

发文量

期刊介绍： The JPAD Journal of Prevention of Alzheimer’Disease will publish reviews, original research articles and short reports to improve our knowledge in the field of Alzheimer prevention including: neurosciences, biomarkers, imaging, epidemiology, public health, physical cognitive exercise, nutrition, risk and protective factors, drug development, trials design, and heath economic outcomes.JPAD will publish also the meeting abstracts from Clinical Trial on Alzheimer Disease (CTAD) and will be distributed both in paper and online version worldwide.We hope that JPAD with your contribution will play a role in the development of Alzheimer prevention.