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引用次数: 0
摘要
摘要SMC(染色体结构维护)复合体是所有生物体(细菌、古生物和真核生物)中 DNA 空间组织的关键参与者。在细菌中,有几种 SMC 复合物的同源物,它们执行看似无关的功能,但通过非常相似且高度保守的机制发挥作用。近年来,人们发现 SMC 复合物能够从 DNA 上形成环(通过所谓的环挤压),这使它们可以被视为一类独立的 DNA 易位酶。本文将讨论细菌 SMC 复合物与其同源物(如 MukBEF、MksBEF、RecN 和 Wadjet)以及真核生物 SMC 复合物的比较。本文讨论了它们在细菌细胞关键过程中的特性、作用和功能。
Organization and Role of Bacterial SMC, MukBEF, MksBEF, Wadjet, and RecN Complexes
Abstract
SMC (Structural maintenance of chromosomes) complexes are key participants in the spatial organization of DNA in all living organisms: in bacteria, archaea and eukaryotes. In bacteria, there are several homologues of SMC complexes that perform seemingly unrelated functions, but function through very similar, highly conserved mechanisms. In recent years, it has been established that SMC complexes are capable of forming loops from DNA (through the so-called loop extrusion), which allows them to be considered as a separate class of DNA translocases. This paper discusses bacterial SMC complexes in comparison with their homologues such as MukBEF, MksBEF, RecN, and Wadjet, as well as with eukaryotic SMC complexes. Their properties, role and functions in the key processes of the bacterial cell are discussed.
期刊介绍:
The journal publishes papers on vast aspects of cell research, including morphology, biochemistry, biophysics, genetics, molecular biology, immunology. The journal accepts original experimental studies, theoretical articles suggesting novel principles and approaches, presentations of new hypotheses, reviews highlighting major developments in cell biology, discussions. The main objective of the journal is to provide a competent representation and integration of research made on cells (animal and plant cells, both in vivo and in cell culture) offering insight into the structure and functions of live cells as a whole. Characteristically, the journal publishes articles on biology of free-living and parasitic protists, which, unlike Metazoa, are eukaryotic organisms at the cellular level of organization.