ANGPTL4 的 T266M 变体通过改变与阻塞性睡眠呼吸暂停患者乙酰-CoA 羧化酶的结合亲和力改善脂质代谢

IF 4.9 2区医学 Q1 MEDICINE, GENERAL & INTERNAL

Annals of medicine Pub Date : 2024-04-04 DOI:10.1080/07853890.2024.2337740

Xinyi Li, Chenyang Li, Wenjun Xue, Zhicheng Wei, Hangdong Shen, Kejia Wu, Huaming Zhu, Huajun Xu, Xiaolin Wu, Hongliang Yi, Jian Guan, Shankai Yin

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引用次数: 0

摘要

血管生成素样蛋白 4（ANGPTL4）被认为是脂质代谢的重要调节因子。乙酰-CoA羧化酶（ACACAs）在脂肪酸的β-氧化过程中发挥作用。然而，...

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T266M variants of ANGPTL4 improve lipid metabolism by modifying their binding affinity to acetyl-CoA carboxylase in obstructive sleep apnea

Angiopoietin-like protein 4 (ANGPTL4) is recognized as a crucial regulator in lipid metabolism. Acetyl-CoA carboxylases (ACACAs) play a role in the β-oxidation of fatty acids. Yet, the functions of...

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来源期刊

Annals of medicine 医学-医学：内科

CiteScore

4.90

自引率

0.00%

发文量

292

审稿时长

3 months

期刊介绍： Annals of Medicine is one of the world’s leading general medical review journals, boasting an impact factor of 5.435. It presents high-quality topical review articles, commissioned by the Editors and Editorial Committee, as well as original articles. The journal provides the current opinion on recent developments across the major medical specialties, with a particular focus on internal medicine. The peer-reviewed content of the journal keeps readers updated on the latest advances in the understanding of the pathogenesis of diseases, and in how molecular medicine and genetics can be applied in daily clinical practice.