利用多极共振元表面对结构照明显微镜进行空间波前整形 [特邀]

IF 2.8 3区 材料科学 Q3 MATERIALS SCIENCE, MULTIDISCIPLINARY
Tamal Roy, Peter T. Brown, Douglas P. Shepherd, and Lisa V. Poulikakos
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引用次数: 0

摘要

结构照明显微镜(SIM)通过图案化照明和计算图像重建实现了荧光成像的超分辨率,但目前的方法需要笨重、昂贵的调制光学器件和高精度光学对准,从而阻碍了 SIM 的广泛应用。为了应对这一挑战,这项工作展示了如何合理设计纳米光学元表面以在亚波长尺寸上定制远场光波前,从而为 SIM 的超薄、单面、全光波前调制器带来巨大潜力。我们用一个由硅纳米结构组成的多极共振元表面对这一原理进行了计算演示,当入射光的偏振或角度发生变化时,元表面会在远场产生多变的光波面。通过算法优化,我们根据三个关键标准为元表面产生的 SIM 确定了七种最合适的照明模式。我们定量证明了多极共振元表面 SIM(mrm-SIM)可实现与传统方法相当的分辨率增益,具体方法是将元表面生成的七种最佳波面应用于模拟荧光物体,并使用近端梯度下降法重建物体。值得注意的是,我们展示了 mrm-SIM 利用远场照明模式实现了这些分辨率增益,从而避开了同类方法所需的复杂设备和校准要求。本文介绍的工作为元表面支持的结构照明显微镜实验简化铺平了道路。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Spatial wavefront shaping with a multipolar-resonant metasurface for structured illumination microscopy [Invited]
Structured illumination microscopy (SIM) achieves superresolution in fluorescence imaging through patterned illumination and computational image reconstruction, yet current methods require bulky, costly modulation optics and high-precision optical alignment, thus hindering the widespread implementation of SIM. To address this challenge, this work demonstrates how nano-optical metasurfaces, rationally designed to tailor the far-field optical wavefront at sub-wavelength dimensions, hold great potential as ultrathin, single-surface, all-optical wavefront modulators for SIM. We computationally demonstrate this principle with a multipolar-resonant metasurface composed of silicon nanostructures that generate versatile optical wavefronts in the far field upon variation of the polarization or angle of incident light. Algorithmic optimization is performed to identify the seven most suitable illumination patterns for SIM generated by the metasurface based on three key criteria. We quantitatively demonstrate that multipolar-resonant metasurface SIM (mrm-SIM) achieves resolution gain that is comparable to conventional methods by applying the seven optimal metasurface-generated wavefronts to simulated fluorescent objects and reconstructing the objects using proximal gradient descent. Notably, we show that mrm-SIM achieves these resolution gains with a far-field illumination pattern that circumvents complex equipment and alignment requirements of comparable methodologies. The work presented here paves the way for a metasurface-enabled experimental simplification of structured illumination microscopy.
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来源期刊
Optical Materials Express
Optical Materials Express MATERIALS SCIENCE, MULTIDISCIPLINARY-OPTICS
CiteScore
5.50
自引率
3.60%
发文量
377
审稿时长
1.5 months
期刊介绍: The Optical Society (OSA) publishes high-quality, peer-reviewed articles in its portfolio of journals, which serve the full breadth of the optics and photonics community. Optical Materials Express (OMEx), OSA''s open-access, rapid-review journal, primarily emphasizes advances in both conventional and novel optical materials, their properties, theory and modeling, synthesis and fabrication approaches for optics and photonics; how such materials contribute to novel optical behavior; and how they enable new or improved optical devices. The journal covers a full range of topics, including, but not limited to: Artificially engineered optical structures Biomaterials Optical detector materials Optical storage media Materials for integrated optics Nonlinear optical materials Laser materials Metamaterials Nanomaterials Organics and polymers Soft materials IR materials Materials for fiber optics Hybrid technologies Materials for quantum photonics Optical Materials Express considers original research articles, feature issue contributions, invited reviews, and comments on published articles. The Journal also publishes occasional short, timely opinion articles from experts and thought-leaders in the field on current or emerging topic areas that are generating significant interest.
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