Ayşe Karadeniz-Yildirim, Suat Ozkorucuklu, Handan Tanyildizi-Kokkulunk, Mustafa Demir, Dogan Yasar
{"title":"使用门:三维模型对钇-90 放射性核素的肝脏剂量测定进行蒙特卡罗模拟","authors":"Ayşe Karadeniz-Yildirim, Suat Ozkorucuklu, Handan Tanyildizi-Kokkulunk, Mustafa Demir, Dogan Yasar","doi":"10.3103/S1068335623600201","DOIUrl":null,"url":null,"abstract":"<p>This study is aimed to validate <sup>90</sup>Y dosimetry with MC simulation by comparing the TLD measurements results obtained in 3D liqid phantom (LP) and its monte carlo (MC) simulation. In the first step, tumor imitation was filled with 1900 µCi (70.3 MBq) amount of <sup>99m</sup>Tc activity in LP. In addition, 24 thermoluminescence dosimetry chips (TLD-100) were placed in 8 different locations in the LP. The same measurement system was created in GEANT4 Tomography Emission Application (GATE version 8.1). DoseActor library was defined for 24 points instead of TLDs and doses were taken. In the second step, <sup>90</sup>Y with the amount of 2 mCi (74 MBq) activity and 27 DoseActor libraries were placed in tumor mimic and different locations in LP to calculate the dose distribution with GATE. GATE and TLD results for <sup>99m</sup>Tc were compared for validation. The strong correlation coefficient was calculated between the instant absorbed dose rates obtained via TLD measurements and GATE calculations as <i>R</i><sup>2</sup> = 0.994. At the <sup>90</sup>Y dosimetry, the highest, lowest and mean cumulative absorbed doses calculated by GATE for a half-life were found to be 1.166 × 10<sup>2</sup> ± 3.907 × 10<sup>–1</sup>, 5.440 × 10<sup>1</sup> ± 2.597 × 10<sup>–1</sup>, and 75.145 ± 0.303 Gy in the tumor imitation, and 1.167 × 10<sup>1</sup> ± 1.777 × 10<sup>−1</sup>, 9.929 × 10<sup>−5</sup> ± 6.905 × 10<sup>−5</sup>, 1.169 ± 0.019 Gy in the liver parenchymal tissue imitation, respectively. GATE program is considered to be a promising application in internal radionuclide dosimetry, based on linear correlation between TLD and GATE measurements in our study.</p>","PeriodicalId":503,"journal":{"name":"Bulletin of the Lebedev Physics Institute","volume":null,"pages":null},"PeriodicalIF":0.6000,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Monte Carlo Simulation of Liver Dosimetry with Yttrium-90 Radionuclide Using Gate: 3D Phantom\",\"authors\":\"Ayşe Karadeniz-Yildirim, Suat Ozkorucuklu, Handan Tanyildizi-Kokkulunk, Mustafa Demir, Dogan Yasar\",\"doi\":\"10.3103/S1068335623600201\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>This study is aimed to validate <sup>90</sup>Y dosimetry with MC simulation by comparing the TLD measurements results obtained in 3D liqid phantom (LP) and its monte carlo (MC) simulation. In the first step, tumor imitation was filled with 1900 µCi (70.3 MBq) amount of <sup>99m</sup>Tc activity in LP. In addition, 24 thermoluminescence dosimetry chips (TLD-100) were placed in 8 different locations in the LP. The same measurement system was created in GEANT4 Tomography Emission Application (GATE version 8.1). DoseActor library was defined for 24 points instead of TLDs and doses were taken. In the second step, <sup>90</sup>Y with the amount of 2 mCi (74 MBq) activity and 27 DoseActor libraries were placed in tumor mimic and different locations in LP to calculate the dose distribution with GATE. GATE and TLD results for <sup>99m</sup>Tc were compared for validation. The strong correlation coefficient was calculated between the instant absorbed dose rates obtained via TLD measurements and GATE calculations as <i>R</i><sup>2</sup> = 0.994. At the <sup>90</sup>Y dosimetry, the highest, lowest and mean cumulative absorbed doses calculated by GATE for a half-life were found to be 1.166 × 10<sup>2</sup> ± 3.907 × 10<sup>–1</sup>, 5.440 × 10<sup>1</sup> ± 2.597 × 10<sup>–1</sup>, and 75.145 ± 0.303 Gy in the tumor imitation, and 1.167 × 10<sup>1</sup> ± 1.777 × 10<sup>−1</sup>, 9.929 × 10<sup>−5</sup> ± 6.905 × 10<sup>−5</sup>, 1.169 ± 0.019 Gy in the liver parenchymal tissue imitation, respectively. GATE program is considered to be a promising application in internal radionuclide dosimetry, based on linear correlation between TLD and GATE measurements in our study.</p>\",\"PeriodicalId\":503,\"journal\":{\"name\":\"Bulletin of the Lebedev Physics Institute\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.6000,\"publicationDate\":\"2024-04-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Bulletin of the Lebedev Physics Institute\",\"FirstCategoryId\":\"101\",\"ListUrlMain\":\"https://link.springer.com/article/10.3103/S1068335623600201\",\"RegionNum\":4,\"RegionCategory\":\"物理与天体物理\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"PHYSICS, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bulletin of the Lebedev Physics Institute","FirstCategoryId":"101","ListUrlMain":"https://link.springer.com/article/10.3103/S1068335623600201","RegionNum":4,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"PHYSICS, MULTIDISCIPLINARY","Score":null,"Total":0}
Monte Carlo Simulation of Liver Dosimetry with Yttrium-90 Radionuclide Using Gate: 3D Phantom
This study is aimed to validate 90Y dosimetry with MC simulation by comparing the TLD measurements results obtained in 3D liqid phantom (LP) and its monte carlo (MC) simulation. In the first step, tumor imitation was filled with 1900 µCi (70.3 MBq) amount of 99mTc activity in LP. In addition, 24 thermoluminescence dosimetry chips (TLD-100) were placed in 8 different locations in the LP. The same measurement system was created in GEANT4 Tomography Emission Application (GATE version 8.1). DoseActor library was defined for 24 points instead of TLDs and doses were taken. In the second step, 90Y with the amount of 2 mCi (74 MBq) activity and 27 DoseActor libraries were placed in tumor mimic and different locations in LP to calculate the dose distribution with GATE. GATE and TLD results for 99mTc were compared for validation. The strong correlation coefficient was calculated between the instant absorbed dose rates obtained via TLD measurements and GATE calculations as R2 = 0.994. At the 90Y dosimetry, the highest, lowest and mean cumulative absorbed doses calculated by GATE for a half-life were found to be 1.166 × 102 ± 3.907 × 10–1, 5.440 × 101 ± 2.597 × 10–1, and 75.145 ± 0.303 Gy in the tumor imitation, and 1.167 × 101 ± 1.777 × 10−1, 9.929 × 10−5 ± 6.905 × 10−5, 1.169 ± 0.019 Gy in the liver parenchymal tissue imitation, respectively. GATE program is considered to be a promising application in internal radionuclide dosimetry, based on linear correlation between TLD and GATE measurements in our study.
期刊介绍:
Bulletin of the Lebedev Physics Institute is an international peer reviewed journal that publishes results of new original experimental and theoretical studies on all topics of physics: theoretical physics; atomic and molecular physics; nuclear physics; optics; lasers; condensed matter; physics of solids; biophysics, and others.