肿瘤微环境中癌症干细胞与免疫细胞之间的串扰促进肝癌进展

IF 3.9 3区医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL

Frontiers of Medicine Pub Date : 2024-04-11 DOI:10.1007/s11684-023-1049-z

Yue Ma, Hongwei Lv, Fuxue Xing, Wei Xiang, Zixin Wu, Qiyu Feng, Hongyang Wang, Wen Yang

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引用次数: 0

摘要

癌细胞与免疫微环境之间的相互影响是肝癌进展的决定性因素。一种被称为肝癌干细胞（CSCs）的肿瘤亚群在肝癌的发生、转移、抗药性和复发中起着重要作用。新的证据表明，肝癌干细胞与免疫细胞之间的相互作用在形成免疫抑制微环境和决定免疫疗法反应方面起着至关重要的作用。本综述在概述了肝脏干细胞的特征及其微环境之后，揭示了肝脏干细胞与免疫细胞之间的双向交叉作用对肝癌进展的影响，以及其潜在的分子机制。最后，我们讨论了肝脏干细胞靶向免疫疗法在肝癌治疗中的潜在应用。

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Cancer stem cell-immune cell crosstalk in the tumor microenvironment for liver cancer progression

Crosstalk between cancer cells and the immune microenvironment is determinant for liver cancer progression. A tumor subpopulation called liver cancer stem cells (CSCs) significantly accounts for the initiation, metastasis, therapeutic resistance, and recurrence of liver cancer. Emerging evidence demonstrates that the interaction between liver CSCs and immune cells plays a crucial role in shaping an immunosuppressive microenvironment and determining immunotherapy responses. This review sheds light on the bidirectional crosstalk between liver CSCs and immune cells for liver cancer progression, as well as the underlying molecular mechanisms after presenting an overview of liver CSCs characteristic and their microenvironment. Finally, we discuss the potential application of liver CSCs-targeted immunotherapy for liver cancer treatment.

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来源期刊

Frontiers of Medicine ONCOLOGYMEDICINE, RESEARCH & EXPERIMENTAL&-MEDICINE, RESEARCH & EXPERIMENTAL

CiteScore

18.30

自引率

0.00%

发文量

800

期刊介绍： Frontiers of Medicine is an international general medical journal sponsored by the Ministry of Education of China. The journal is jointly published by the Higher Education Press and Springer. Since the first issue of 2010, this journal has been indexed in PubMed/MEDLINE. Frontiers of Medicine is dedicated to publishing original research and review articles on the latest advances in clinical and basic medicine with a focus on epidemiology, traditional Chinese medicine, translational research, healthcare, public health and health policies.