胰腺脂肪变的药理前景

IF 13 1区医学 Q1 PHARMACOLOGY & PHARMACY

Drugs Pub Date : 2024-04-04 DOI:10.1007/s40265-024-02022-7

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引用次数: 0

摘要

摘要研究减少胰腺内脂肪沉积的药物已有四分之一个世纪的历史。虽然目前还没有治疗胰腺脂肪变的特效药物获得批准，但药物再利用显示了减轻胰腺最常见疾病负担的希望。这篇权威文章概述了迄今为止为减少胰腺内脂肪沉积而研究的 12 类药物。文章分层次介绍了从临床前研究、人体回顾性研究结果、前瞻性干预研究到随机对照试验等方面的信息。这为通过精心设计的基础科学研究和充分有效的随机对照试验，将最具潜力的药物应用于医疗实践奠定了基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The Pharmacological Landscape for Fatty Change of the Pancreas

Abstract

The quest for medications to reduce intra-pancreatic fat deposition is now quarter a century old. While no specific medication has been approved for the treatment of fatty change of the pancreas, drug repurposing shows promise in reducing the burden of the most common disorder of the pancreas. This leading article outlines the 12 classes of medications that have been investigated to date with a view to reducing intra-pancreatic fat deposition. Information is presented hierarchically—from preclinical studies to retrospective findings in humans to prospective interventional studies to randomised controlled trials. This lays the grounds for shepherding the most propitious drugs into medical practice through well-designed basic science studies and adequately powered randomised controlled trials.

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来源期刊

Drugs 医学-毒理学

CiteScore

22.70

自引率

0.90%

发文量

134

审稿时长

3-8 weeks

期刊介绍： Drugs is a journal that aims to enhance pharmacotherapy by publishing review and original research articles on key aspects of clinical pharmacology and therapeutics. The journal includes: Leading/current opinion articles providing an overview of contentious or emerging issues. Definitive reviews of drugs and drug classes, and their place in disease management. Therapy in Practice articles including recommendations for specific clinical situations. High-quality, well designed, original clinical research. Adis Drug Evaluations reviewing the properties and place in therapy of both newer and established drugs. AdisInsight Reports summarising development at first global approval. Moreover, the journal offers additional digital features such as animated abstracts, video abstracts, instructional videos, and podcasts to increase visibility and educational value. Plain language summaries accompany articles to assist readers with some knowledge of the field in understanding important medical advances.