使用不同方法合成芳香族叠氮化物

IF 1.7 3区 化学 Q3 CHEMISTRY, ORGANIC
Elisa Leyva, Silvia E. Loredo-Carrillo
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引用次数: 0

摘要

::几十年来,芳香叠氮化物一直被应用于有机化合物的合成、新型材料和生物大分子的光亲和标记等多个研究领域。点击化学和生物正交化学的发现扩大了它们的应用范围。目前,它们被广泛应用于生物学、生物化学和医学领域。多年来,芳香叠氮化物通常采用亲核取代法制备。在这一经典程序中,市售苯胺首先被转化为芳基重氮盐,然后通过与叠氮化钠的亲核取代作用转化为芳香叠氮化物。然而,这一过程需要使用强酸和低温,因此在实验上非常不便。近年来,人们开发出了几种替代程序。在本综述中,我们介绍了通过不同实验方法合成芳香叠氮化物的过程。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Synthesis of Aromatic Azides using Different Methodologies
:: For several decades, aromatic azides have been applied in diverse areas of research like synthesis of organic compounds, novel materials and photoaffinity labeling of biomolecules. The discovery of click chemistry and bioorthogonal chemistry expanded their applications. Currently, they are extensively used in biology, biochemistry and medicine. For many years, aromatic azides were usually prepared using nucleophilic substitution. In this classical procedure, commercially available anilines are first converted into aryl diazonium salts which in turn are transformed into aromatic azides by nucleophilic substitution with sodium azide. However, this procedure is rather inconvenient experimentally since it requires the use of strong acids and low temperatures. In recent years, several alternative procedures have been developed. In the present review, we present the synthesis of aromatic azides by means of different experimental methodologies.
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来源期刊
Current Organic Chemistry
Current Organic Chemistry 化学-有机化学
CiteScore
3.70
自引率
7.70%
发文量
76
审稿时长
1 months
期刊介绍: Current Organic Chemistry aims to provide in-depth/mini reviews on the current progress in various fields related to organic chemistry including bioorganic chemistry, organo-metallic chemistry, asymmetric synthesis, heterocyclic chemistry, natural product chemistry, catalytic and green chemistry, suitable aspects of medicinal chemistry and polymer chemistry, as well as analytical methods in organic chemistry. The frontier reviews provide the current state of knowledge in these fields and are written by chosen experts who are internationally known for their eminent research contributions. The Journal also accepts high quality research papers focusing on hot topics, highlights and letters besides thematic issues in these fields. Current Organic Chemistry should prove to be of great interest to organic chemists in academia and industry, who wish to keep abreast with recent developments in key fields of organic chemistry.
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