新型甲灭酸 1,3,4-恶二唑衍生物的合成、表征和分子建模

IF 0.7 4区工程技术 Q4 CHEMISTRY, APPLIED

Polish Journal of Chemical Technology Pub Date : 2024-04-03 DOI:10.2478/pjct-2024-0016

Mashooq A. Bhat, Ahmed M. Naglah, Ahmed Hassan Bakheit, Mohamad A. Al-Omar

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引用次数: 0

摘要

通过甲灭酸酰肼与无水乙酸酐反应，获得了一系列新型的甲灭酸 1,3,4-噁二唑衍生物。甲灭酸酰肼是由不同的取代醛与甲灭酸酰肼反应得到的。所有化合物都通过光谱数据和元素分析进行了表征。针对 COX-1/COX-2 酶对所有化合物进行了分子对接研究。发现化合物 4 和化合物 10 与 COX-1 结合的可能性最大，而化合物 3、化合物 6 和化合物 10 与 COX-2 酶结合的可能性最大。

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Synthesis, characterization, and molecular modeling of novel 1,3,4-oxadiazole derivatives of mefenamic acid

A novel series of 1,3,4-oxadiazole derivatives of mefenamic acid was obtained by reacting hydrazones of mefenamic acid with anhydrous acetic anhydride. The mefenamic hydrazones were obtained by reacting different substituted aldehydes with mefenamic acid hydrazide. All the compounds were characterized by spectral data and elemental analysis. Molecular docking studies of all the compounds were performed against COX-1/COX-2 enzymes. Compound 4 and compound 10 were found to have the highest potential to bind with COX-1 while compound 3, compound 6, and compound 10 were found to have the highest potential to bind with COX-2 enzyme.

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来源期刊

Polish Journal of Chemical Technology CHEMISTRY, APPLIED-ENGINEERING, CHEMICAL

CiteScore

1.70

自引率

10.00%

发文量

审稿时长

4.5 months

期刊介绍： Polish Journal of Chemical Technology is a peer-reviewed, international journal devoted to fundamental and applied chemistry, as well as chemical engineering and biotechnology research. It has a very broad scope but favors interdisciplinary research that bring chemical technology together with other disciplines. All authors receive very fast and comprehensive peer-review. Additionally, every published article is promoted to researchers working in the same field.