数百万年的自然实验：大规模比较基因组学及其对人类健康的影响

IF 3.3 3区医学 Q2 EVOLUTIONARY BIOLOGY

Evolution, Medicine, and Public Health Pub Date : 2024-04-02 DOI:10.1093/emph/eoae006

Iker Rivas-González, Jenny Tung

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引用次数: 0

摘要

提高非人类哺乳动物基因组组装的多样性和质量一直是比较基因组学的长期目标。去年，我们在实现这一目标方面取得了实质性进展，包括发布了 240 种哺乳动物和近一半灵长目动物的基因组序列。这些资源提高了我们识别基因组进化受限区域的能力，共同有力地证明了这些区域对人类生物医学相关性状变异的重要性。它们还提供了新的策略，用于确定各个品系独特变化的遗传基础，说明了进化比较方法对了解人类健康的价值。

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A multi-million-year natural experiment: comparative genomics on a massive scale and its implications for human health

Improving the diversity and quality of genome assemblies for non-human mammals has been a long-standing goal of comparative genomics. The last year saw substantial progress towards this goal, including the release of genome alignments for 240 mammals and nearly half the primate order. These resources have increased our ability to identify evolutionarily constrained regions of the genome, and together strongly support the importance of these regions to biomedically relevant trait variation in humans. They also provide new strategies for identifying the genetic basis of changes unique to individual lineages, illustrating the value of evolutionary comparative approaches for understanding human health

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来源期刊

Evolution, Medicine, and Public Health Environmental Science-Health, Toxicology and Mutagenesis

CiteScore

5.40

自引率

2.70%

发文量

审稿时长

8 weeks

期刊介绍： About the Journal Founded by Stephen Stearns in 2013, Evolution, Medicine, and Public Health is an open access journal that publishes original, rigorous applications of evolutionary science to issues in medicine and public health. It aims to connect evolutionary biology with the health sciences to produce insights that may reduce suffering and save lives. Because evolutionary biology is a basic science that reaches across many disciplines, this journal is open to contributions on a broad range of topics.