丹参素与厄贝沙坦的药物相互作用及其潜在机制

IF 1.3 4区医学 Q4 PHARMACOLOGY & PHARMACY

Xenobiotica Pub Date : 2024-04-09 DOI:10.1080/00498254.2024.2338183

Yuexia Li, Liheng Liu

引用次数: 0

摘要

1.揭示丹参素对厄贝沙坦药代动力学的影响及其内在机制。2. 为研究丹参素对厄贝沙坦药代动力学的影响，用Sprague-Dawley小鼠、Sprague-Dawley大鼠和Sprague-Dawley...

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Drug-drug interaction between danshensu and irbesartan and its potential mechanism

1. To uncover the effect of danshensu on irbesartan pharmacokinetics and its underlying mechanisms.2. To investigate the effect of danshensu on the pharmacokinetics of irbesartan, Sprague-Dawley ra...

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来源期刊

Xenobiotica 医学-毒理学

CiteScore

3.80

自引率

5.60%

发文量

审稿时长

2 months

期刊介绍： Xenobiotica covers seven main areas, including:General Xenobiochemistry, including in vitro studies concerned with the metabolism, disposition and excretion of drugs, and other xenobiotics, as well as the structure, function and regulation of associated enzymesClinical Pharmacokinetics and Metabolism, covering the pharmacokinetics and absorption, distribution, metabolism and excretion of drugs and other xenobiotics in manAnimal Pharmacokinetics and Metabolism, covering the pharmacokinetics, and absorption, distribution, metabolism and excretion of drugs and other xenobiotics in animalsPharmacogenetics, defined as the identification and functional characterisation of polymorphic genes that encode xenobiotic metabolising enzymes and transporters that may result in altered enzymatic, cellular and clinical responses to xenobioticsMolecular Toxicology, concerning the mechanisms of toxicity and the study of toxicology of xenobiotics at the molecular levelXenobiotic Transporters, concerned with all aspects of the carrier proteins involved in the movement of xenobiotics into and out of cells, and their impact on pharmacokinetic behaviour in animals and manTopics in Xenobiochemistry, in the form of reviews and commentaries are primarily intended to be a critical analysis of the issue, wherein the author offers opinions on the relevance of data or of a particular experimental approach or methodology