从定量参数映射到髓鞘水分数的转换图:与白质中的 R1-R2* 和髓鞘水分数进行比较

IF 2 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Shun Kitano, Yuki Kanazawa, Masafumi Harada, Yo Taniguchi, Hiroaki Hayashi, Yuki Matsumoto, Kosuke Ito, Yoshitaka Bito, Akihiro Haga
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引用次数: 0

摘要

目的阐明髓鞘水分数(MWF)与R1⋅R2*之间的关系,并开发一种直接从QPM得出的参数计算MWF的方法,即从QPM转换而来的MWF(MWFQPM)。在 3 T MR 扫描仪上,使用 QPM 的破坏梯度回波序列获取数据集。从多梯度回波(mGRE)数据集导出 MWF 和 R1⋅R2* 图。使用 JHU-白质(WM)图谱进行了兴趣容积(VOI)分析。绘制了 48 个白质区域的所有测量 VOI 数据,并根据 R1-R2* 和双池模型-MWF 之间的关系得出了每个区域的二次多项式近似值。将 R1-R2* 图转换为 MWFQPM 图。结果 48 个 WM 区域的平均 MWF 和 R1-R2* 值分别为 11.96 ± 6.63% 和 19.94 ± 4.59 s-2。与 mGRE-MWF 地图相比,MWFQPM 地图提高了图像质量。由 MWFQPM 导出的髓鞘水图谱模板可结合多个 WM 区域生成。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Conversion map from quantitative parameter mapping to myelin water fraction: comparison with R1·R2* and myelin water fraction in white matter

Conversion map from quantitative parameter mapping to myelin water fraction: comparison with R1·R2* and myelin water fraction in white matter

Objective

To clarify the relationship between myelin water fraction (MWF) and R1R2* and to develop a method to calculate MWF directly from parameters derived from QPM, i.e., MWF converted from QPM (MWFQPM).

Materials and methods

Subjects were 12 healthy volunteers. On a 3 T MR scanner, dataset was acquired using spoiled gradient-echo sequence for QPM. MWF and R1R2* maps were derived from the multi-gradient-echo (mGRE) dataset. Volume-of-interest (VOI) analysis using the JHU-white matter (WM) atlas was performed. All the data in the 48 WM regions measured VOI were plotted, and quadratic polynomial approximations of each region were derived from the relationship between R1·R2* and the two-pool model-MWF. The R1·R2* map was converted to MWFQPM map. MWF atlas template was generated using converted to MWF from R1·R2* per WM region.

Results

The mean MWF and R1·R2* values for the 48 WM regions were 11.96 ± 6.63%, and 19.94 ± 4.59 s−2, respectively. A non-linear relationship in 48 regions of the WM between MWF and R1·R2* values was observed by quadratic polynomial approximation (R2 ≥ 0.963, P < 0.0001).

Discussion

MWFQPM map improved image quality compared to the mGRE-MWF map. Myelin water atlas template derived from MWFQPM may be generated with combined multiple WM regions.

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来源期刊
CiteScore
4.60
自引率
0.00%
发文量
58
审稿时长
>12 weeks
期刊介绍: MAGMA is a multidisciplinary international journal devoted to the publication of articles on all aspects of magnetic resonance techniques and their applications in medicine and biology. MAGMA currently publishes research papers, reviews, letters to the editor, and commentaries, six times a year. The subject areas covered by MAGMA include: advances in materials, hardware and software in magnetic resonance technology, new developments and results in research and practical applications of magnetic resonance imaging and spectroscopy related to biology and medicine, study of animal models and intact cells using magnetic resonance, reports of clinical trials on humans and clinical validation of magnetic resonance protocols.
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