m6A 修饰对癌症中 ncRNA 的影响

IF 1.8 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Current Genomics Pub Date : 2024-04-15 DOI:10.2174/0113892029296712240405053201

Rashid Mehmood

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引用次数: 0

摘要

::N6-甲基腺苷（m6A）是一种 RNA 修饰，其中腺苷的 N6 位被甲基化。它是 RNA 最常见的内部修饰之一，调节着 RNA 代谢的各个方面。M6A 由 m6A 甲基转移酶沉积，由 m6A 去甲基化酶去除，并被阅读蛋白识别，从而调节经修饰的 mRNA 的剪接、输出、翻译和稳定性。最近的证据表明，各种非编码 RNA（ncRNA），包括微 RNA（miRNA）、环状 RNA（circRNA）和长共编码 RNA（lncRNA），也是这种修饰的靶标。根据 ncRNA 种类的不同，m6A 可能会影响这些分子的加工、稳定性或定位。经 m6A 修饰的 ncRNA 与癌症等多种疾病有关。在这篇综述中，作者总结了 m6A 修饰在肿瘤发生过程中 ncRNAs 的调控和功能中的作用。此外，还讨论了在癌症预后和治疗中的潜在应用。

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Ramifications of m6A Modification on ncRNAs in Cancer

:: N6-methyladenosine (m6A) is an RNA modification wherein the N6-position of adenosine is methylated. It is one of the most prevalent internal modifications of RNA and regulates various aspects of RNA metabolism. M6A is deposited by m6A methyltransferases, removed by m6A demethylases, and recognized by reader proteins, which modulate splicing, export, translation, and stability of the modified mRNA. Recent evidence suggests that various classes of non-- coding RNAs (ncRNAs), including microRNAs (miRNAs), circular RNAs (circRNAs), and long con-coding RNAs (lncRNAs), are also targeted by this modification. Depending on the ncRNA species, m6A may affect the processing, stability, or localization of these molecules. The m6A-- modified ncRNAs are implicated in a number of diseases, including cancer. In this review, the author summarizes the role of m6A modification in the regulation and functions of ncRNAs in tumor development. Moreover, the potential applications in cancer prognosis and therapeutics are discussed.

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来源期刊

Current Genomics 生物-生化与分子生物学

CiteScore

5.20

自引率

0.00%

发文量

审稿时长

>0 weeks

期刊介绍： Current Genomics is a peer-reviewed journal that provides essential reading about the latest and most important developments in genome science and related fields of research. Systems biology, systems modeling, machine learning, network inference, bioinformatics, computational biology, epigenetics, single cell genomics, extracellular vesicles, quantitative biology, and synthetic biology for the study of evolution, development, maintenance, aging and that of human health, human diseases, clinical genomics and precision medicine are topics of particular interest. The journal covers plant genomics. The journal will not consider articles dealing with breeding and livestock. Current Genomics publishes three types of articles including: i) Research papers from internationally-recognized experts reporting on new and original data generated at the genome scale level. Position papers dealing with new or challenging methodological approaches, whether experimental or mathematical, are greatly welcome in this section. ii) Authoritative and comprehensive full-length or mini reviews from widely recognized experts, covering the latest developments in genome science and related fields of research such as systems biology, statistics and machine learning, quantitative biology, and precision medicine. Proposals for mini-hot topics (2-3 review papers) and full hot topics (6-8 review papers) guest edited by internationally-recognized experts are welcome in this section. Hot topic proposals should not contain original data and they should contain articles originating from at least 2 different countries. iii) Opinion papers from internationally recognized experts addressing contemporary questions and issues in the field of genome science and systems biology and basic and clinical research practices.