辅助生殖与先天性畸形:系统回顾和荟萃分析

IF 1.3 4区 医学 Q3 PEDIATRICS
Meenakshi Veeramani, Neerujah Balachandren, Yong Hwa Hong, Jiyoon Lee, Antonio F. Corno, Dimitrios Mavrelos, Stavroula L. Kastora
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引用次数: 0

摘要

先前的研究探讨了先天性畸形与辅助生殖技术等因素之间的联系。然而,目前仍不清楚某种特定技术是否存在先天性畸形的固有风险,无论是累积风险还是器官特异性风险。我们利用六个数据库和两个适当的登记册,对从开始到 2023 年 2 月的相关研究进行了荟萃分析。通过子组分析、研究权重、偏倚风险和原始研究的地理位置,探讨了异质性的来源。与自然受孕的新生儿相比,通过辅助生殖受孕的新生儿发生重大先天性异常的风险似乎更高,OR 0.67 [95% CI 0.59, 0.76], I2 = 97%, p < 0.00001,其中通过卵胞浆内单精子显微注射(ICSI)受孕的新生儿与通过体外受精(IVF)受孕的新生儿相比,患病几率要高出 9%。心脏、胃肠道(GI)和神经系统先天性畸形的增加似乎与辅助生殖技术无关,而泌尿生殖系统和肌肉骨骼(MSK)畸形在ICSI与体外受精相比有所增加,OR值分别为0.83 [95% CI 0.69, 0.98];P = 0.03,I2 = 0%,OR值分别为0.65 [95% CI 0.49, 0.85];P = 0.002,I2 = 80%。使用辅助生殖技术受孕的新生儿出现重大先天畸形的风险似乎更高,而使用卵胞浆内单精子显微注射技术受孕的风险更高。心脏、神经和消化道先天畸形的增加似乎与辅助生殖技术无关,而泌尿生殖系统和骨骼肌畸形的增加则与此相反。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Assisted reproduction and congenital malformations: A systematic review and meta-analysis

Assisted reproduction and congenital malformations: A systematic review and meta-analysis

Prior studies have explored the links between congenital anomalies and assisted reproduction techniques, among other factors. However, it remains unclear whether a particular technique harbors an inherent risk of major congenital anomalies, either cumulatively or in an organ-specific manner. A meta-analysis was conducted using relevant studies from inception to February 2023 using six databases and two appropriate registers. Sources of heterogeneity were explored using sub-group analysis, using study weight, risk of bias and geographical location of original studies. Neonates conceived through assisted reproduction appear to have a higher risk of major congenital anomalies compared to naturally conceived neonates, OR 0.67 [95% CI 0.59, 0.76], I2 = 97%, p < 0.00001, with neonates conceived through intracytoplasmic sperm injection (ICSI) at a 9% higher chance of being affected in comparison to neonates conceived through in vitro fertilization (IVF). The increase in cardiac, gastrointestinal (GI), and neurological congenital anomalies appears to be independent of the assisted reproduction technique, while urogenital and musculoskeletal (MSK) anomalies were found to be increased in ICSI compared with IVF, OR 0.83 [95% CI 0.69, 0.98]; p = 0.03, I2 = 0%, and OR 0.65 [95% CI 0.49, 0.85]; p = 0.002, I2 = 80%, respectively. Neonates conceived using assisted reproduction techniques appear to be at higher risk of major congenital anomalies, with a higher risk attributable to conception using ICSI. The increase in cardiac, neurological, and GI congenital anomalies does not appear to be technique-specific, while the opposite held true for urogenital and MSK anomalies.

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来源期刊
Congenital Anomalies
Congenital Anomalies PEDIATRICS-
自引率
0.00%
发文量
49
审稿时长
>12 weeks
期刊介绍: Congenital Anomalies is the official English language journal of the Japanese Teratology Society, and publishes original articles in laboratory as well as clinical research in all areas of abnormal development and related fields, from all over the world. Although contributions by members of the teratology societies affiliated with The International Federation of Teratology Societies are given priority, contributions from non-members are welcomed.
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