在旋转蒸发器辅助下快速合成环缩醛和环缩酮

IF 1.7 4区化学 Q3 CHEMISTRY, ORGANIC

Synlett Pub Date : 2024-04-08 DOI:10.1055/a-2293-3243

Fuyao Jiang, Yinzhe Chen, Weiding Wang, Qian Zhang

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引用次数: 0

摘要

在此，我们介绍一种利用旋转蒸发仪合成环状缩醛和缩酮的快速高效方法。与通常需要较长反应时间和大量有机溶剂的传统迪安-斯塔克脱水工艺不同，我们的方法只需使用极少量的二甲亚砜作为溶剂，就能在 30 分钟内合成不同环径的环醛和环酮。这一创新方案的特点是产率高、反应快、操作简便、底物适用性广。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Rapid Cyclic Acetal and Cyclic Ketal Synthesis Assisted by a Rotary Evaporator

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Rapid Cyclic Acetal and Cyclic Ketal Synthesis Assisted by a Rotary Evaporator

Herein, we present a rapid and efficient method for synthesizing cyclic acetals and ketals utilizing a rotary evaporator. Unlike the conventional Dean–Stark dehydration process, which typically demands extended reaction times and copious amounts of organic solvents, our approach affords the synthesis of cyclic acetals and ketals with varying ring sizes in 30 min while using minimal quantities of dimethyl sulfoxide as the solvent. This innovative protocol features high yields, fast reactions, easy operation, and broad substrate applicability.

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来源期刊

Synlett 化学-有机化学

CiteScore

3.40

自引率

5.00%

发文量

369

审稿时长

1 months

期刊介绍： SYNLETT is an international journal reporting research results and current trends in chemical synthesis in short personalized reviews and preliminary communications. It covers all fields of scientific endeavor that involve organic synthesis, including catalysis, organometallic, medicinal, biological, and photochemistry, but also related disciplines and offers the possibility to publish scientific primary data.