通过铜催化的自由基级联环化合成熔环吡咯烷衍生物

IF 1.7 4区化学 Q3 CHEMISTRY, ORGANIC

Synlett Pub Date : 2024-04-03 DOI:10.1055/a-2290-1682

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引用次数: 0

摘要

本文成功开发了一种原子经济的方法，在二叔丁基过氧化物存在下，通过易获得的 N-取代吡咯-2-甲醛与 N-取代马来酰亚胺的环加成反应合成融合环吡咯烷衍生物。利用这种方法共获得了 23 个化合物，最高收率达 72%，为合成三环吡咯烷框架提供了一种实用高效的方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Synthesis of Fused-Ring Pyrrolizine Derivatives via a Copper-Catalyzed Radical Cascade Cyclization

Herein, an atom-economic method for the synthesis of fused-ring pyrrolizine derivatives by a cycloaddition reaction of easily accessible N-substituted pyrrole-2-carboxaldehydes with N-substituted maleimides in the presence of di-tert-butyl peroxide has been successfully developed. A total of 23 compounds were obtained by using this method, with a maximum yield of 72%, providing a practical and efficient method for the synthesis of tricyclic pyrrolizine frameworks.

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来源期刊

Synlett 化学-有机化学

CiteScore

3.40

自引率

5.00%

发文量

369

审稿时长

1 months

期刊介绍： SYNLETT is an international journal reporting research results and current trends in chemical synthesis in short personalized reviews and preliminary communications. It covers all fields of scientific endeavor that involve organic synthesis, including catalysis, organometallic, medicinal, biological, and photochemistry, but also related disciplines and offers the possibility to publish scientific primary data.