Luis F. Gonzalez-Cuyar , Gill Nelson , Susan Searles Nielsen , Wendy W. Dlamini , Amelia Keyser-Gibson , C. Dirk Keene , Michael Paulsen , Susan R. Criswell , Natalie Senini , Lianne Sheppard , Shar Samy , Christopher D. Simpson , Marissa G. Baker , Brad A. Racette
{"title":"接触锰的矿工的嗅道/球状金属浓度","authors":"Luis F. Gonzalez-Cuyar , Gill Nelson , Susan Searles Nielsen , Wendy W. Dlamini , Amelia Keyser-Gibson , C. Dirk Keene , Michael Paulsen , Susan R. Criswell , Natalie Senini , Lianne Sheppard , Shar Samy , Christopher D. Simpson , Marissa G. Baker , Brad A. Racette","doi":"10.1016/j.neuro.2024.04.001","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>Manganese (Mn) is an essential micronutrient as well as a well-established neurotoxicant. Occupational and environmental exposures may bypass homeostatic regulation and lead to increased systemic Mn levels. Translocation of ultrafine ambient airborne particles via nasal neuronal pathway to olfactory bulb and tract may be an important pathway by which Mn enters the central nervous system.</p></div><div><h3>Objective</h3><p>To measure olfactory tract/bulb tissue metal concentrations in Mn-exposed and non-exposed mineworkers.</p></div><div><h3>Methods</h3><p>Using inductively coupled plasma-mass spectrometry (ICP-MS), we measured and compared tissue metal concentrations in unilateral olfactory tracts/bulbs of 24 Mn-exposed and 17 non-exposed South African mineworkers. We used linear regression to investigate the association between cumulative Mn exposures and olfactory tract/bulb Mn concentration.</p></div><div><h3>Results</h3><p>The difference in mean olfactory tract/bulb Mn concentrations between Mn-exposed and non-Mn exposed mineworkers was 0.16 µg/g (95% CI −0.11, 0.42); but decreased to 0.09 µg/g (95% CI 0.004, 0.18) after exclusion of one influential observation. Olfactory tract/bulb metal concentration and cumulative Mn exposure suggested there may be a positive association; for each mg Mn/m<sup>3</sup>-year there was a 0.05 µg/g (95% CI 0.01, 0.08) greater olfactory tract/bulb Mn concentration overall, but −0.003 (95% CI −0.02, 0.02) when excluding the three influential observations. Recency of Mn exposure was not associated with olfactory tract/bulb Mn concentration.</p></div><div><h3>Conclusions</h3><p>Our findings suggest that Mn-exposed mineworkers might have higher olfactory tract/bulb tissue Mn concentrations than non-Mn exposed mineworkers, and that concentrations might depend more on cumulative dose than recency of exposure.</p></div>","PeriodicalId":19189,"journal":{"name":"Neurotoxicology","volume":"102 ","pages":"Pages 96-105"},"PeriodicalIF":3.4000,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Olfactory tract/bulb metal concentration in Manganese-exposed mineworkers\",\"authors\":\"Luis F. Gonzalez-Cuyar , Gill Nelson , Susan Searles Nielsen , Wendy W. Dlamini , Amelia Keyser-Gibson , C. Dirk Keene , Michael Paulsen , Susan R. Criswell , Natalie Senini , Lianne Sheppard , Shar Samy , Christopher D. Simpson , Marissa G. Baker , Brad A. Racette\",\"doi\":\"10.1016/j.neuro.2024.04.001\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><p>Manganese (Mn) is an essential micronutrient as well as a well-established neurotoxicant. Occupational and environmental exposures may bypass homeostatic regulation and lead to increased systemic Mn levels. Translocation of ultrafine ambient airborne particles via nasal neuronal pathway to olfactory bulb and tract may be an important pathway by which Mn enters the central nervous system.</p></div><div><h3>Objective</h3><p>To measure olfactory tract/bulb tissue metal concentrations in Mn-exposed and non-exposed mineworkers.</p></div><div><h3>Methods</h3><p>Using inductively coupled plasma-mass spectrometry (ICP-MS), we measured and compared tissue metal concentrations in unilateral olfactory tracts/bulbs of 24 Mn-exposed and 17 non-exposed South African mineworkers. We used linear regression to investigate the association between cumulative Mn exposures and olfactory tract/bulb Mn concentration.</p></div><div><h3>Results</h3><p>The difference in mean olfactory tract/bulb Mn concentrations between Mn-exposed and non-Mn exposed mineworkers was 0.16 µg/g (95% CI −0.11, 0.42); but decreased to 0.09 µg/g (95% CI 0.004, 0.18) after exclusion of one influential observation. Olfactory tract/bulb metal concentration and cumulative Mn exposure suggested there may be a positive association; for each mg Mn/m<sup>3</sup>-year there was a 0.05 µg/g (95% CI 0.01, 0.08) greater olfactory tract/bulb Mn concentration overall, but −0.003 (95% CI −0.02, 0.02) when excluding the three influential observations. Recency of Mn exposure was not associated with olfactory tract/bulb Mn concentration.</p></div><div><h3>Conclusions</h3><p>Our findings suggest that Mn-exposed mineworkers might have higher olfactory tract/bulb tissue Mn concentrations than non-Mn exposed mineworkers, and that concentrations might depend more on cumulative dose than recency of exposure.</p></div>\",\"PeriodicalId\":19189,\"journal\":{\"name\":\"Neurotoxicology\",\"volume\":\"102 \",\"pages\":\"Pages 96-105\"},\"PeriodicalIF\":3.4000,\"publicationDate\":\"2024-04-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Neurotoxicology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0161813X24000329\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"NEUROSCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neurotoxicology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0161813X24000329","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
引用次数: 0
摘要
背景锰(Mn)是一种必需的微量营养元素,也是一种公认的神经毒物。职业和环境暴露可能会绕过体内平衡调节,导致全身锰含量增加。环境空气中的超细颗粒通过鼻腔神经元途径转移到嗅球和嗅道,这可能是锰进入中枢神经系统的重要途径。方法我们使用电感耦合等离子体质谱仪(ICP-MS)测量并比较了 24 名接触锰的南非矿工和 17 名未接触锰的南非矿工单侧嗅道/嗅球组织中的金属浓度。结果暴露于锰的矿工与未暴露于锰的矿工的平均嗅道/球部锰浓度差异为 0.16 µg/g (95% CI -0.11, 0.42);但在排除一个有影响的观察结果后,差异降至 0.09 µg/g (95% CI 0.004, 0.18)。嗅道/球茎金属浓度与累积锰暴露量可能存在正相关;每毫克锰/立方米-年,嗅道/球茎锰浓度总体上会增加 0.05 微克/克(95% CI 0.01,0.08),但如果排除三个有影响的观测值,则会增加-0.003(95% CI -0.02,0.02)。我们的研究结果表明,与未接触锰的矿工相比,接触锰的矿工的嗅道/球部组织锰浓度可能更高,而且锰浓度可能更多地取决于累积剂量,而不是接触锰的时间。
Olfactory tract/bulb metal concentration in Manganese-exposed mineworkers
Background
Manganese (Mn) is an essential micronutrient as well as a well-established neurotoxicant. Occupational and environmental exposures may bypass homeostatic regulation and lead to increased systemic Mn levels. Translocation of ultrafine ambient airborne particles via nasal neuronal pathway to olfactory bulb and tract may be an important pathway by which Mn enters the central nervous system.
Objective
To measure olfactory tract/bulb tissue metal concentrations in Mn-exposed and non-exposed mineworkers.
Methods
Using inductively coupled plasma-mass spectrometry (ICP-MS), we measured and compared tissue metal concentrations in unilateral olfactory tracts/bulbs of 24 Mn-exposed and 17 non-exposed South African mineworkers. We used linear regression to investigate the association between cumulative Mn exposures and olfactory tract/bulb Mn concentration.
Results
The difference in mean olfactory tract/bulb Mn concentrations between Mn-exposed and non-Mn exposed mineworkers was 0.16 µg/g (95% CI −0.11, 0.42); but decreased to 0.09 µg/g (95% CI 0.004, 0.18) after exclusion of one influential observation. Olfactory tract/bulb metal concentration and cumulative Mn exposure suggested there may be a positive association; for each mg Mn/m3-year there was a 0.05 µg/g (95% CI 0.01, 0.08) greater olfactory tract/bulb Mn concentration overall, but −0.003 (95% CI −0.02, 0.02) when excluding the three influential observations. Recency of Mn exposure was not associated with olfactory tract/bulb Mn concentration.
Conclusions
Our findings suggest that Mn-exposed mineworkers might have higher olfactory tract/bulb tissue Mn concentrations than non-Mn exposed mineworkers, and that concentrations might depend more on cumulative dose than recency of exposure.
期刊介绍:
NeuroToxicology specializes in publishing the best peer-reviewed original research papers dealing with the effects of toxic substances on the nervous system of humans and experimental animals of all ages. The Journal emphasizes papers dealing with the neurotoxic effects of environmentally significant chemical hazards, manufactured drugs and naturally occurring compounds.