基于行为终点,评估三聚氰胺通过系统给药或口服给药对成年斑马鱼的亚慢性毒性

IF 3.4 3区 医学 Q2 NEUROSCIENCES
Hsiu-Chao Chen , Wen-Wei Feng , Gilbert Audira , Kevin Adi Kurnia , San-Ho Hung , Agnes L. Castillo , Marri Jmelou M. Roldan , Chung-Der Hsiao , Chih-Hsin Hung
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引用次数: 0

摘要

市场上发现了受三聚氰胺污染的产品,引发了食品安全问题。最近在啮齿动物和人类身上进行的研究表明,三聚氰胺具有毒性,尤其是会造成肾损伤和膀胱结石。然而,很少有研究对三聚氰胺在生物体(包括鱼类)中的行为毒性进行评估。因此,在这项研究中,研究人员旨在确定通过口服和系统地亚慢性接触三聚氰胺是否会诱发斑马鱼的行为异常。斑马鱼系统地接触0.1ppm和10ppm剂量的三聚氰胺14天后,进行了多种行为测定。两种接触途径的结果表明,三聚氰胺确实会略微增加鱼类的运动量,并改变它们在新水槽试验中的探索行为。此外,在水上接触组中,经处理的鱼类也表现出了更强的趋向性。然而,在其他行为测试中,接触三聚氰胺并没有导致鱼类行为的明显改变。此外,与之前发表的几种溶剂对斑马鱼行为毒性的数据相比,我们的表型组学分析表明,与这些溶剂相比,三聚氰胺通过系统接触或口服给药对斑马鱼的行为毒性相对较低。尽管如此,我们的数据表明,长期低剂量三聚氰胺的潜在神经毒性不容忽视。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Evaluation of sub-chronic toxicity of melamine via systematic or oral delivery in adult zebrafish based on behavioral endpoints

Evaluation of sub-chronic toxicity of melamine via systematic or oral delivery in adult zebrafish based on behavioral endpoints

Melamine-tainted products have been found in the market and raised issues about food safety. Recent studies done in rodents and humans demonstrated the toxicities of melamine, especially in causing kidney damage and bladder stone formation. However, very few studies assessed its behavior toxicity in organisms, including fish. Therefore, in this study, the researchers aim to determine whether sub-chronic exposure to melamine via oral and systematic administration could induce behavioral abnormality in zebrafish. After 14 days of systematic exposure to melamine at doses of 0.1 and 10 ppm levels, zebrafish were subjected to multiple behavioral assays. Results from both exposure routes showed that melamine indeed slightly increased fish locomotion and altered their exploratory behaviors in the novel tank assay. Furthermore, tightened shoaling formation was also displayed by the treated fish in the waterborne exposure group. However, melamine exposure did not cause any obvious alterations in fish behaviors during other behavioral tests. In addition, in comparison with previously published data on the behavior toxicities of several solvents in zebrafish, our phenomic analysis suggests the relatively low behavior toxicities of melamine via either systematic exposure or oral administration to zebrafish compared to those solvents. Nevertheless, our data indicate that the potential neurotoxicity of chronic low-dose melamine should not be ignored.

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来源期刊
Neurotoxicology
Neurotoxicology 医学-毒理学
CiteScore
6.80
自引率
5.90%
发文量
161
审稿时长
70 days
期刊介绍: NeuroToxicology specializes in publishing the best peer-reviewed original research papers dealing with the effects of toxic substances on the nervous system of humans and experimental animals of all ages. The Journal emphasizes papers dealing with the neurotoxic effects of environmentally significant chemical hazards, manufactured drugs and naturally occurring compounds.
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