Nienke D. Sijtsema , Iris Lauwers , Gerda M. Verduijn , Mischa S. Hoogeman , Dirk H.J. Poot , Juan A. Hernandez-Tamames , Aad van der Lugt , Marta E. Capala , Steven F. Petit
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The aim of this study was to relate <em>ADC</em> and NG-IVIM DWI parameters to HPV status and clinical treatment response.</p></div><div><h3>Materials and methods</h3><p>Thirty-six patients (18 HPV-positive, 18 HPV-negative) were prospectively included. Presence of progressive disease was scored within one year. The mean pre-treatment <em>ADC</em> and NG-IVIM parameters in the gross tumor volume were compared between HPV-positive and HPV-negative patients. In HPV-negative patients, <em>ADC</em> and NG-IVIM parameters were compared between patients with and without progressive disease.</p></div><div><h3>Results</h3><p><em>ADC</em>, the NG-IVIM diffusion coefficient <em>D</em>, and perfusion fraction <em>f</em> were significantly higher, while pseudo-diffusion coefficient <em>D*</em> and kurtosis <em>K</em> were significantly lower in the HPV-negative compared to HPV-positive patients. In the HPV-negative group, a significantly lower <em>D</em> was found for patients with progressive disease compared to complete responders. No relation with <em>ADC</em> was observed.</p></div><div><h3>Conclusion</h3><p>The results of our single-center study suggest that <em>ADC</em> is related to HPV status, but not an independent response predictor. The NG-IVIM parameter <em>D,</em> however, was independently associated to response in the HPV-negative group. Noteworthy in the opposite direction as previously thought based on <em>ADC</em>.</p></div>","PeriodicalId":36850,"journal":{"name":"Physics and Imaging in Radiation Oncology","volume":null,"pages":null},"PeriodicalIF":3.4000,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2405631624000447/pdfft?md5=21e7ad76975caaf833ab8dd40588c057&pid=1-s2.0-S2405631624000447-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Relating pre-treatment non-Gaussian intravoxel incoherent motion diffusion-weighted imaging to human papillomavirus status and response in oropharyngeal carcinoma\",\"authors\":\"Nienke D. Sijtsema , Iris Lauwers , Gerda M. Verduijn , Mischa S. Hoogeman , Dirk H.J. Poot , Juan A. Hernandez-Tamames , Aad van der Lugt , Marta E. Capala , Steven F. 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引用次数: 0
摘要
背景和目的扩散加权成像(DWI)是一种用于头颈部癌症反应评估的有前途的技术。最近,我们优化了头颈部的非高斯体内相干运动成像(NG-IVIM),这是传统表观弥散系数(ADC)模型的扩展。在本研究中,我们描述了在一组人乳头瘤病毒(HPV)阳性和 HPV 阴性口咽鳞癌患者中的首次应用。这项研究的目的是将 ADC 和 NG-IVIM DWI 参数与 HPV 状态和临床治疗反应联系起来。对一年内是否出现进展性疾病进行评分。比较了HPV阳性和HPV阴性患者治疗前肿瘤总体积的平均ADC和NG-IVIM参数。结果 HPV 阴性患者的 ADC、NG-IVIM 弥散系数 D 和灌注分数 f 明显高于 HPV 阳性患者,而伪弥散系数 D* 和峰度 K 则明显低于 HPV 阳性患者。在HPV阴性组中,疾病进展患者的D明显低于完全应答者。结论我们的单中心研究结果表明,ADC与HPV状态有关,但不是独立的反应预测因子。然而,在HPV阴性组中,NG-IVIM参数D与反应有独立关系。值得注意的是,这与之前根据 ADC 得出的结论方向相反。
Relating pre-treatment non-Gaussian intravoxel incoherent motion diffusion-weighted imaging to human papillomavirus status and response in oropharyngeal carcinoma
Background and purpose
Diffusion-weighted imaging (DWI) is a promising technique for response assessment in head-and-neck cancer. Recently, we optimized Non-Gaussian Intravoxel Incoherent Motion Imaging (NG-IVIM), an extension of the conventional apparent diffusion coefficient (ADC) model, for the head and neck. In the current study, we describe the first application in a group of patients with human papillomavirus (HPV)-positive and HPV-negative oropharyngeal squamous cell carcinoma. The aim of this study was to relate ADC and NG-IVIM DWI parameters to HPV status and clinical treatment response.
Materials and methods
Thirty-six patients (18 HPV-positive, 18 HPV-negative) were prospectively included. Presence of progressive disease was scored within one year. The mean pre-treatment ADC and NG-IVIM parameters in the gross tumor volume were compared between HPV-positive and HPV-negative patients. In HPV-negative patients, ADC and NG-IVIM parameters were compared between patients with and without progressive disease.
Results
ADC, the NG-IVIM diffusion coefficient D, and perfusion fraction f were significantly higher, while pseudo-diffusion coefficient D* and kurtosis K were significantly lower in the HPV-negative compared to HPV-positive patients. In the HPV-negative group, a significantly lower D was found for patients with progressive disease compared to complete responders. No relation with ADC was observed.
Conclusion
The results of our single-center study suggest that ADC is related to HPV status, but not an independent response predictor. The NG-IVIM parameter D, however, was independently associated to response in the HPV-negative group. Noteworthy in the opposite direction as previously thought based on ADC.