Ruifei Yang, Siqi Jin, Suyun Fang, Dawei Yan, Hao Zhang, Jingru Nie, Jinqiao Liu, Minjuan Lv, Bo Zhang, Xinxing Dong
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引用次数: 0
摘要
基因流动对于提高牲畜的经济性状至关重要。在中国,几十年来育种者一直在使用杂交策略来提高家畜的性能。在这里,我们对中国本土的丽江猪(LJP)品种进行了全基因组测序。通过整合之前已发表的数据,我们探索了丽江猪的遗传结构以及欧洲商品猪(EP)基因成分对丽江猪的导入,并研究了这种导入对表型性状的影响。我们的分析表明,欧洲猪种在 LJP 和中国其他国内猪种中有明显的导入。利用基于单倍型的方法,我们量化了引种水平,并将 EP 与 LJP 及其他中国家猪进行了比较。结果表明,尽管不同猪种之间存在显著差异,但 EP 引种在中国家猪中广泛存在。我们认为,LJP 有可能是 EP 单倍型传播的媒介。我们还研究了 EP 导入与 LJP 胸椎数量之间的相关性,并确定 VRTN 和 STUM 为该性状的候选基因。我们的研究提供了在LJP品种中引入欧洲单倍型的证据,并描述了EP引入对这一本土品种表型变化的潜在作用。
Genetic introgression from commercial European pigs to the indigenous Chinese Lijiang breed and associated changes in phenotypes
Gene flow is crucial for enhancing economic traits of livestock. In China, breeders have used hybridization strategies for decades to improve livestock performance. Here, we performed whole-genome sequencing of a native Chinese Lijiang pig (LJP) breed. By integrating previously published data, we explored the genetic structure and introgression of genetic components from commercial European pigs (EP) into the LJP, and examined the impact of this introgression on phenotypic traits. Our analysis revealed significant introgression of EP breeds into the LJP and other domestic pig breeds in China. Using a haplotype-based approach, we quantified introgression levels and compared EP to LJP and other Chinese domestic pigs. The results show that EP introgression is widely prevalent in Chinese domestic pigs, although there are significant differences between breeds. We propose that LJP could potentially act as a mediator for the transmission of EP haplotypes. We also examined the correlation between EP introgression and the number of thoracic vertebrae in LJP and identified VRTN and STUM as candidate genes for this trait. Our study provides evidence of introgressed European haplotypes in the LJP breed and describes the potential role of EP introgression on phenotypic changes of this indigenous breed.
期刊介绍:
Genetics Selection Evolution invites basic, applied and methodological content that will aid the current understanding and the utilization of genetic variability in domestic animal species. Although the focus is on domestic animal species, research on other species is invited if it contributes to the understanding of the use of genetic variability in domestic animals. Genetics Selection Evolution publishes results from all levels of study, from the gene to the quantitative trait, from the individual to the population, the breed or the species. Contributions concerning both the biological approach, from molecular genetics to quantitative genetics, as well as the mathematical approach, from population genetics to statistics, are welcome. Specific areas of interest include but are not limited to: gene and QTL identification, mapping and characterization, analysis of new phenotypes, high-throughput SNP data analysis, functional genomics, cytogenetics, genetic diversity of populations and breeds, genetic evaluation, applied and experimental selection, genomic selection, selection efficiency, and statistical methodology for the genetic analysis of phenotypes with quantitative and mixed inheritance.