Clinical Symptoms of the Systemic Inflammatory Response in Acute Severe Poisoning by Agents Affecting the Central Nervous System

Relevance. Currently, acute poisoning with substances affecting the central nervous system in the general structure of exogenous intoxications accounts for up to 50-60% of cases, of which up to 25% are severe and extremely severe lesions leading to the formation of critical conditions and requiring intensive care (Bonitenko E.Yu. et al., 2018; Luzhnikov E.A. et al., 2016; Bohnert A.S. et al., 2019; Muller D. et al., 2017; Taheri F. et al., 2015). The causes of widespread acute poisoning include the uncontrolled use of various medicines in everyday life, suicidal attempts, as well as the use of narcotic drugs for the purpose of drug intoxication (Rokhlina M.L., 2019; Nordstrom D. L. et al., 2017; Taheri F. et al., 2018). The severity of the condition of patients with acute severe poisoning by drugs affecting the central nervous system is due to pronounced disorders of the functions of various organs and body systems due to the specific action of xenobiotics (Luzhnikov E.A. et al., 2016), as well as developing hypoxia (Livanov G.A. et al., 2014; Hashemian M. et al., 2016), leading to the development of life-threatening complications, which often determines the outcome of chemical trauma.