马拉喀什穆罕默德六世全民健康中心 Ibn Tofail 医院创伤科术后感染的流行病学研究

S. Khayati, R. Rada, L. A. Said, K. Zahlane
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摘要

导言:术后感染是导致外科死亡和发病的主要原因之一。术后感染是创伤手术中的一种严重并发症,限制了手术干预的潜在效益。材料和方法:我们的工作是一项前瞻性描述性研究,从 2017 年 1 月到 12 月,历时一年,样本在创伤整形科采集,然后在马拉喀什穆罕默德六世中央医院 Ibn Tofail 医院细菌学实验室进行分析。所有接受过手术并在术后至少 72 小时内出现术后感染的患者均被纳入研究范围。研究结果在研究期间,78 名手术对象共确诊 55 例术后感染。分离出的病菌数量为 112 种,其中 70% 为 BGN,30% 为 CGP。细菌科的分布显示,肠杆菌科细菌占分离菌的 46%,其次是葡萄球菌(26%),然后是不发酵的 BGN(24%)和链球菌(4%)。细菌的耐药性水平显示,所有鲍曼尼氏菌都对亚胺培南耐药,70%的肠杆菌科细菌表现出高度耐药性,50%的铜绿假单胞菌对头孢他啶耐药,而 MRSA 的耐药率为 47%。多重耐药菌主要是 ABRI(34%),其次是产 ESBL 肠杆菌科(EBLSE)(29%)、MRSA(20%)、碳青霉烯类肠杆菌科(ECARBA)(10%)和 PARC(7%)。ECARBAs 对氨基糖苷类药物具有高度耐药性。EBLSE和ABRI对氨基糖苷类和喹诺酮类药物均有耐药性。对于 MRSA,只有 Teicoplanin 和万古霉素对这些细菌仍然有效。最后,PARC 对所有抗生素家族都表现出很强的耐药性。所有菌株都对可乐定敏感。结论外伤术后感染有多种风险因素,其中最重要的因素与护理不当、有时技术平台不尽如人意、病理状态先进有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Epidemiology of Post-Operative Infections in Traumatology Services, Hospital Ibn Tofail, Mohammed VI UHC of Marrakech
Introduction: Post-operative infections are one of the leading causes of mortality and morbidity in surgery. They represent a serious complication in trauma surgery and limit the potential benefit of surgical interventions. Material and method: Our work is a prospective descriptive study carried out over a period of one year, going from January to December 2017, the samples of which were taken at the level of the traumatology-orthopedics department, then analyzed in the bacteriology laboratory, the Ibn Tofail hospital, CHU Mohamed VI of Marrakech. All patients who had undergone surgery and subsequently developed postoperative infection at least 72 hours after surgery were included in the study. Result: During the study period 55 postoperative infections were diagnosed in 78 operated subjects. The number of germs isolated is 112, 70% of which are BGN and 30% CGP. The distribution by bacterial family demonstrated the predominance of Enterobacteriaceae which represented 46% of isolates, followed by Staphylococci (26%), then nonfermenting BGNs (24%), and Streptococci (4%). The level of resistance of bacteria had shown that all A. baumannii strains were resistant to imipenem, 70% of Enterobacteriaceae showed high level resistance, then 50% of P. aeruginosa were resistant to ceftazidime, and the MRSA rate was 47%. Multidrug resistant bacteria are dominated by ABRI (34%), followed by ESBL-producing Enterobacteriaceae (EBLSE) (29%), MRSA (20%), Carbapenemasous Enterobacteriaceae (ECARBA) (10%) and PARC (7%). ECARBAs exhibit a high level of resistance to aminoglycosides. Both EBLSEs and ABRI were resistant to aminoglycosides and quinolones. For MRSA, only teicoplanin and vancomycin remain active on these bacteria. Finally, PARC showed strong resistance to all antibiotic families. All strains were sensitive to colistin. Conclusion: There are multiple risk factors for postoperative infections in trauma, the most important of which are related to inadequate practices in adequate care, sometimes unsatisfactory technical platforms, advanced state of pathologies.
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