调查高海拔对肌生成素和鸢尾素水平影响的试点研究

Q3 Pharmacology, Toxicology and Pharmaceutics
Richa Rathor, G. Suryakumar, Somnath Singh
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引用次数: 0

摘要

许多人由于探险或职业原因前往高海拔地区并在那里逗留。高海拔环境中存在许多与海洋居民格格不入的因素,不利于身心健康。肌动蛋白是肌肉分泌的多肽和细胞因子,在调节骨骼肌生长和肌肉退化方面发挥着重要作用。因此,本研究调查了肌动蛋白在急性和慢性高海拔暴露期间调节肌肉质量的功能。研究对象为印度健康受试者(29 人),他们被分为三组:对照组(海平面,人数=15)、急性高海拔逗留受试者(在高海拔逗留少于十天,人数=7)、慢性高海拔逗留受试者(在高海拔逗留 15 天至 3 个月(CHA,人数=7))。急性高海拔暴露会导致肌生成蛋白水平升高,表明肌降解作用增强。与SL组相比,AHA组的鸢尾素水平也有所增加,表明肌生成倾斜。然而,CHA组与SL组相比,肌生成蛋白水平增加,但鸢尾素含量变化不明显,表明肌降解增强。这些研究结果表明,肌动蛋白(包括肌节蛋白和鸢尾素)在高海拔地区骨骼肌健康管理中发挥着独特的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A Pilot Study Investigating the Impact of High Altitude on Myostatin and Irisin Levels
Many people visit and stay at high altitude due to adventure or occupation. The high-altitude environment comprises many factors alien to sea residents and detrimental to physical and mental health. Myokines are peptides and cytokines secreted from muscles and have a prime role in regulating skeletal muscle growth and myo-degradation. Therefore, the present study investigated the function of myokines in regulating muscle mass during acute and chronic high-altitude exposure. The study was conducted on Indian healthy subjects (n=29) who were distributed into three groups: Control (sea level (SL; n=15), acute high altitude stayed subjects (stayed at high altitude for less than ten days (AHA; n=7); chronic high altitude stayed subjects (stayed at high altitude for 15 days to 3 months (CHA; n=7). Acute exposure to high altitude leads to an increase in myostatin levels, indicating enhanced myo-degradation. Irisin levels were also increased in AHA group compared to SL group, depicting inclined myogenesis. However, CHA group showed an increase in myostatin levels but a non-significant change in irisin content in relation to SL group, suggesting enhanced myo-degradation. These findings generated a unique role of myokines, including myostatin and irisin, in managing skeletal muscle health with reference to high altitude. 
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来源期刊
Defence Life Science Journal
Defence Life Science Journal Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)
CiteScore
0.80
自引率
0.00%
发文量
26
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