过去和现在对抗高海拔缺氧诱发疾病的潜在候选分子

Q3 Pharmacology, Toxicology and Pharmaceutics
Shweta Kushwaha, Deepika Saraswat
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引用次数: 0

摘要

低压缺氧发生在气压较低的高海拔地区,会导致氧气供应不足,从而引发多种高海拔疾病,如急性高山症(AMS)、高海拔肺水肿(HAPE)、高海拔脑水肿(HACE)等。高原反应症状,如头痛、恶心、疲倦,通常在 1-2 天内消失。乙酰唑胺、地塞米松、硝苯地平是用于治疗的药物,它们对碳酸酐酶、钙通道起作用。乙酰唑胺能提高动脉血氧分压,硝苯地平能放松血管平滑肌,增加血流量。有些药物还会产生副作用,如头晕、利尿、恶心、乏力等。因此,需要寻找更有针对性、副作用更小的新药,以便在高海拔地区更快地缓解症状,获得更好的健康。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Potential Candidate Molecules of Past and Present for Combating High Altitude Hypoxia Induced Maladies
Hypobaric hypoxia occurs at high altitudes where barometric pressure is low causing insufficient supply of oxygen leading to many high-altitude illnesses like acute mountain sickness (AMS), high altitude pulmonary edema (HAPE), high altitude cerebral edema (HACE) etc.Medications have been applied to treat and prevent injuries caused by HBH, showing anti-inflammatory, anti-edemagenic, and antioxidant properties. AMS symptoms, such as headache, nausea, weariness, usually go away in 1-2 days. HACE causes brain swelling, elevated intracranial pressure, resulting in confusion, stupor, ataxia, and death.Acetazolamide, dexamethasone, nifedipine are the drugs used for treatment acting oncarbonic anhydrase enzyme, calcium channels.Acetazolamide increases arterial partial pressure of oxygen.Nifedipine relaxes vascular smooth muscles and increases blood flow. Some drugscause side effects also like dizziness, diuresis, nausea, malaise, etc. Hence, a new drug search is needed to find more targeted and fewer side effects for faster relief and better health at high altitudes.
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来源期刊
Defence Life Science Journal
Defence Life Science Journal Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)
CiteScore
0.80
自引率
0.00%
发文量
26
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