Posterior Shrinkage Towards Linear Subspaces

It is common to hold prior beliefs that are not characterized by points in the parameter space but instead are relational in nature and can be described by a linear subspace. While some previous work has been done to account for such prior beliefs, the focus has primarily been on point estimators within a regression framework. We argue, however, that prior beliefs about parameters ought to be encoded into the prior distribution rather than in the formation of a point estimator. In this way, the prior beliefs help shape \textit{all} inference. Through exponential tilting, we propose a fully generalizable method of taking existing prior information from, e.g., a pilot study, and combining it with additional prior beliefs represented by parameters lying on a linear subspace. We provide computationally efficient algorithms for posterior inference that, once inference is made using a non-tilted prior, does not depend on the sample size. We illustrate our proposed approach on an antihypertensive clinical trial dataset where we shrink towards a power law dose-response relationship, and on monthly influenza and pneumonia data where we shrink moving average lag parameters towards smoothness. Software to implement the proposed approach is provided in the R package \verb+SUBSET+ available on GitHub.