Significance of Inflammatory Markers; C-reactive Protein, Hyperuricemia, and Albuminuria in type 2 Diabetes Patients

Objective:  To determine the significance of inflammatory markers, including C-reactive protein, hyperuricemia, and albuminuria, in individuals with type 2 diabetes. Methodology: This cross-sectional analytical study was done at Diabetic Clinic and Nephrology Department of Akbar Niazi Teaching Hospital, Islamabad between Jan 2023 and July 2023. Total 150 consecutive patients aged between 35 and 60 years with type 2 diabetes were enrolled in study. Participants were divided in two groups on the basis of C-reactive protein and uric acid levels. Group-A comprised individuals with type 2 diabetes and C-reactive protein levels, while Group-B included individuals with type 2 diabetes and uric acid levels. Every patient underwent necessary clinical and laboratory assessments. The measurement of C-reactive protein was conducted through a particle-enhanced immunoturbidimetric assay. Results: The study population demonstrates an average age of 49.41±7.66 years. In linear regression analysis, both C-reactive protein and uric acid emerged as independently predictor the albumin to creatinine ratio include (?=0.20, 95% CI 0.1-0.30, and p=0.001 for C-reactive protein, and ?=0.20, 95% CI 0.1-0.30, and p=0.001 for uric acid). In logistic regression, the albuminuria odd for C-reactive protein and uric acid groups was 4.05 (95% CI 2.60-9.15, p=0.001). Conclusion: In individuals with type 2 diabetes, there was an association observed between albuminuria and heightened levels of C-reactive protein and elevated uric acid levels. Additionally, there was an interactive effect on albuminuria observed between C-reactive protein and uric acid.