将斑马鱼作为研究细胞外囊泡的模型。

O. V. Kalinina, D. B. Sambur, E. E. Koroleva, A. S. Golovkin
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引用次数: 0

摘要

根据文献,评估了使用斑马鱼作为研究细胞外囊泡 (EVs) 模型的可行性。特别是,它描述了用于评估 EVs 在调节病理和生理过程(缺血、再灌注、组织和器官的机械损伤、局部和全身免疫反应的发展、肿瘤生长和转移等)中的贡献、注射 EVs 在不同组织和器官中的生物利用度和分布、外源 EVs 作为治疗剂的效果的实验模型。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Zebrafish as a model for studing extracellular vesicles.
It was evaluated the feasibility of using Zebrafish as a model to study extracellular vesicles (EVs) based on literature. Particularly, it was described experimental models that were used to assess the contribution of the EVs in the regulation of pathological and physiological processes (ischemic, reperfusion, mechanical damage to tissues and organs, development of local and systemic immune response, tumor growth and metastasis, etc.), the bioavailability and the distribution of injected EVs in different tissues and organs, the effects of exogenous EVs as therapeutic agents.
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