犬肾上腺皮质功能亢进症与甲状腺功能减退症相关的病例报告

Paolo Ruggero Errante
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摘要

犬甲状腺功能减退症是一种内分泌失调症,主要是由于甲状腺遭到破坏,继而出现特发性甲状腺变性或特发性滤泡萎缩,导致甲状腺素(T4)和三碘甲状腺原氨酸(T3)激素分泌过低。犬先天性肾上腺皮质功能亢进症是一种因长期使用皮质类固醇进行治疗而引起的疾病,多数情况下是在过敏过程中,如犬过敏症。在本病例报告中,一只 12 岁的雌性雪纳瑞犬因表情淡漠、多食、双侧对称性非瘙痒性脱发(脱发部位延伸至尾尖,但头部和四肢没有脱发)而就诊。其他临床表现包括多尿、多饮和双侧角结膜炎。该动物接受了血细胞计数、T4、T3、促甲状腺激素剂量、地塞米松抑制试验、生化试验和影像学检查。检查结果显示该动物患有肾上腺皮质功能亢进症和甲状腺功能减退症。由于在犬过敏性疾病中使用皮质类固醇会导致肾上腺皮质功能亢进症的发生,而甲状腺功能减退症则是犬最常见的内分泌疾病,因此临床兽医必须能够及早发现这些疾病。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A case report of association between canine iatrogenic hyperadrenocorticism and hypothyroidism
The canine hypothyroidism corresponds to a hormonal disorder, mainly caused by destruction of the thyroid gland, followed by idiopathic thyroid degeneration or idiopathic follicular atrophy, leading to a low production of the hormones thyroxine (T4) and triiodothyronine (T3). The canine iatrogenic hyperadrenocorticism consists of a disorder caused by the prolonged use of corticosteroids for therapeutic purposes, in most cases in allergic processes, such as canine atopy. In this case report, a twelve-year-old female Schnauzer was presented to the clinical facility with signs of apathy, polyphagia and non-pruritic bilateral symmetric alopecia that extended to the tip of the tail but sparing the head and limbs. Other clinical manifestations included polyuria, polydipsia, and bilateral keratoconjunctivitis sicca. The animal was submitted to the blood count, T4, T3, TSH dosage, dexamethasone suppression test, biochemical tests, and imaging tests. Exam results demonstrate the presence of hyperadrenocorticism and hypothyroidism. Since the use of corticosteroids in canine allergic diseases can lead to the development of hyperadrenocorticism, and hypothyroidism corresponds to the most common endocrinopathy in dogs, it is essential that the clinical veterinarian is able to identify these diseases early.
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