紫菀果实绿色溶剂提取物的抗糖尿病和抗炎活性

Q3 Pharmacology, Toxicology and Pharmaceutics

Research Journal of Pharmacy and Technology Pub Date : 2024-01-19 DOI:10.52711/0974-360x.2024.00026

Supriya Dubey, A. Shukla

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引用次数: 0

摘要

背景：植物是植物成分的主要来源，可作为预防和治疗各种疾病的有效药物。Heterospathe elata 属于天南星科植物，具有多种药用特性。本研究旨在调查 Heterospathe elata 果实绿色溶剂提取物的抗糖尿病和抗炎活性。方法：采用异丙醇、氢醇和水等绿色溶剂进行提取，极性依次递增。体外抗糖尿病活性通过α-淀粉酶和α-葡萄糖苷酶抑制试验进行评估。通过博文变性法和 HRBC 膜稳定法评估了抗炎活性。结果：结果表明，在三种绿色提取物中，紫菀果实的水醇提取物具有最高的抗糖尿病和抗炎活性。结论结果表明，紫菀果实具有潜在的抗糖尿病和抗炎特性。

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Antidiabetic and Anti-inflammatory activity of Green Solvent Extracts of Heterospathe elata fruits

Background: Plants are the prime source of phytoconstituents that can act as potent agents for the prevention and treatment of various diseases. Heterospathe elata is a plant belonging to the Arecaceae family having numerous medicinal properties. The present study aimed to investigate the antidiabetic and anti-inflammatory activities of green solvent extracts of Heterospathe elata fruit. Method: The extraction was carried out with green solvents like isopropyl alcohol, hydro alcohol, and water with increasing order of polarity. In-vitro antidiabetic activity was evaluated by alpha-amylase and alpha-glucosidase inhibition assays. Anti-inflammatory activity was evaluated by the Bovin denaturation method and HRBC membrane stabilization. Result: Our results revealed that out of three green extracts hydro alcohol extract of Heterospathe elata fruit had the highest antidiabetic and anti-inflammatory activity. Conclusion: The results suggest that the fruit of Heterospathe elata is a potential source of antidiabetic and anti-inflammatory properties.

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来源期刊

Research Journal of Pharmacy and Technology Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

CiteScore

1.40

自引率

0.00%

发文量

期刊介绍： Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal, devoted to pharmaceutical sciences. The aim of RJPT is to increase the impact of pharmaceutical research both in academia and industry, with strong emphasis on quality and originality. RJPT publishes Original Research Articles, Short Communications, Review Articles in all areas of pharmaceutical sciences from the discovery of a drug up to clinical evaluation. Topics covered are: Pharmaceutics and Pharmacokinetics; Pharmaceutical chemistry including medicinal and analytical chemistry; Pharmacognosy including herbal products standardization and Phytochemistry; Pharmacology: Allied sciences including drug regulatory affairs, Pharmaceutical Marketing, Pharmaceutical Microbiology, Pharmaceutical biochemistry, Pharmaceutical Education and Hospital Pharmacy.