开发和验证散装和配方产品中抗哮喘药物沙美特罗辛纳佛酸盐的用户友好型分析方法

Q3 Pharmacology, Toxicology and Pharmaceutics

Research Journal of Pharmacy and Technology Pub Date : 2024-01-19 DOI:10.52711/0974-360x.2024.00055

Sonal Nalkar, S. Sutar, Mayuresh. R. Redkar, Priyanka More, Pooja Swami

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引用次数: 0

摘要

针对散装和药物制剂中的沙美特罗，建立了一种简便、精确、灵敏、廉价且具有选择性的 RP-HPLC 方法。该方法在 Inertsil ODS C18（250 x 4.6mm，5µ填充）上进行。最大吸光度为 203 纳米。在 20 至 70ppm 浓度范围内，沙美特罗-昔那福酯呈线性关系，相关系数为 0.999。进样量为 20µl，流速为 1.0ml/min。流动相为甲醇和水（60:40 v/v）。运行时间为 8 分钟。保留时间为 3.521。检出限和定量限分别为 0.00471 和 0.01429。

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User Friendly Analytical Method Development and Validation of Salmeterol Xinafoate an Antiasthmatic Drug in Bulk and Formulated Product

A simple, precise, accurate, sensitive cheap and selective RP-HPLC method has been developed of salmeterol in bulk and pharmaceutical formulation. The method was carried out on an Inertsil ODS C18 (250 x 4.6mm, packed with 5µ). The maximum absorbance was found to be at 203nm. The Salmeterol xinafoate followed linearity in the concentration range 20 to 70ppm and correlation coefficient was found to be 0.999. Injection volume was selected to be 20µl and the flow rate was fixed at 1.0ml/min. Mobile phase selected with the ratio of methanol and water (60:40 v/v). Run time was selected to be 8min. Retention team was found to be 3.521. The LOD and LOQ were found to be 0.00471 and 0.01429.

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来源期刊

Research Journal of Pharmacy and Technology Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

CiteScore

1.40

自引率

0.00%

发文量

期刊介绍： Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal, devoted to pharmaceutical sciences. The aim of RJPT is to increase the impact of pharmaceutical research both in academia and industry, with strong emphasis on quality and originality. RJPT publishes Original Research Articles, Short Communications, Review Articles in all areas of pharmaceutical sciences from the discovery of a drug up to clinical evaluation. Topics covered are: Pharmaceutics and Pharmacokinetics; Pharmaceutical chemistry including medicinal and analytical chemistry; Pharmacognosy including herbal products standardization and Phytochemistry; Pharmacology: Allied sciences including drug regulatory affairs, Pharmaceutical Marketing, Pharmaceutical Microbiology, Pharmaceutical biochemistry, Pharmaceutical Education and Hospital Pharmacy.