使用压电石英免疫传感器检测免疫化学反应。电极生物层的再生(综述)

S. S. Gogina, E. A. Smirnova, Ya. M. Stanishevskii, A. M. Stoinova
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引用次数: 0

摘要

导言。最有前途的免疫传感器类型之一是石英晶体微天平免疫传感器(QCM 免疫传感器)。一次性使用的生物传感器对资金要求较高,因此生物传感器表面的再生成为 QCM 免疫传感器的一个相关问题。再生在维持传感器功能和实现其可重复使用性方面发挥着关键作用。在本文中,"免疫传感器 "和 "免疫生物传感器 "是可以互换的术语,用来表示基于抗原和抗体之间免疫化学相互作用的同一类生物传感器。这篇综述讨论了 QCM 免疫传感器的特点、工作原理和应用。其中特别关注了生物传感器表面再生的挑战,这是确保其有效运行和具有多种用途潜力的一个关键方面。本文研究了各种再生方法及其优势。QCM 电极上生物传感层的重新激活可确保其长期稳定性和功能性,这在临床和科学研究中尤为重要。生物传感器可重复使用,降低了材料成本,减少了废物的产生,符合生态和经济方面的要求。此外,在同一表面上分析不同分析物的能力也促进了多参数研究的多功能性。必须强调的是,残留分析物的去除和生物传感器的再生过程提高了可靠性、选择性、灵敏度和可重复性测量的潜力。对科学文献的分析强调了生物传感器再生在保持功能性和可重用性方面的关键作用。抗原-抗体相互作用的强度决定了条件,必须为每对抗原-抗体量身定制。本综述深入探讨了压电传感器再生的三种主要方法,包括使用化学方法、基于氧等离子体的技术和食人鱼溶液的应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Detection of Immunochemical Reactions Using Piezoquartz Immunosensor. Regeneration of the Electrode Bio-layer (Review)
Introduction. One of the most promising types of immunosensors is quartz crystal microbalance immunosensors (QCM immunosensors). Single-use biosensors are financially demanding, thus rendering the regeneration of the biosensor surface a pertinent issue for QCM immunosensors. Regeneration plays a pivotal role in sustaining the functionality of the sensor and enabling its reusability. In this article, "immunosensor" and "immunobiosensor" are interchangeable terms and are used to denote the same type of biosensors operating based on immunochemical interactions between antigens and antibodies.Text. This review discusses the features, operational principles, and applications of QCM immunosensors. Particular attention is directed toward the challenge of regenerating the biosensor surface as a key aspect ensuring their effective operation and the potential for multiple uses. Various regeneration methods and their advantages are examined. The reactivation of the biosensing layer on the QCM electrode secures its stability and functionality over extended periods, which is especially valuable in clinical and scientific research. The possibility of reusing the biosensor reduces material costs and waste production, aligning with ecological and economic concerns. Furthermore, the ability to analyze different analytes on the same surface fosters versatility in multiparametric investigations. It is essential to emphasize that the removal of residual analytes and the biosensor's regeneration process enhance reliability, selectivity, heightened sensitivity, and the potential for reproducible measurements.Conclusion. An analysis of scientific literature underscores the pivotal role of biosensor regeneration in maintaining functionality and reusability. The strength of the antigen-antibody interaction determines the conditions, which must be tailored individually for each antigen-antibody pair. The review thoroughly explores three primary approaches to the regeneration of piezoelectric transducers, including the use of a chemical method, oxygen plasma-based techniques, and the application of Piranha solution.
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