内生菌：尚未开发的抗真菌剂来源

Q2 Pharmacology, Toxicology and Pharmaceutics

Current Bioactive Compounds Pub Date : 2024-01-29 DOI:10.2174/0115734072276049231207110314

Sudesh Kumari, Prity Gulia, Pooja Choudhary, N. Sharma, Sweety Dahiya, Aruna Punia, A. K. Chhillar

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引用次数: 0

摘要

自从抗药性真菌感染出现以来，筛选新型生物活性化合物就变得越来越重要，民族药用植物也开始被用作抗真菌剂。最近，药用植物的研究重点已转向内生菌及其与寄主植物的相互作用和抗真菌活性的筛选。内生菌是一组共生微生物，它们在植物组织内茁壮成长，不会引起任何症状，也不会标明自己的存在。内生菌被视为生产独特生物活性物质的潜在资源。从高等植物中分离出来的内生菌的生物活性天然化合物正受到全世界研究人员的广泛关注，这一点从最近有关抗真菌潜力的研究和出版物的激增中可见一斑。本综述旨在了解内生菌作为抗真菌剂的一种有前途的来源的作用和应用，并介绍其最常见的作用模式。

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Endophytes: Untapped Source of Antifungal Agents

Screening for novel bioactive compounds has become more critical since drugresistant fungal infections have emerged and ethno-medicinal plants have been embarked as antifungal agents. The emphasis on medicinal plants has recently switched to the study of endophytes and their interactions with the host plant and screening of their antifungal activity. Endophytes are an endosymbiotic group of microorganisms that thrive within plant tissues without causing any symptoms or marking their presence. Endophytes have been looked into as potential resources for producing distinctive bioactive substances. The quest for bioactive natural compounds of endophytes isolated from higher plants is receiving a lot of interest from researchers worldwide, as seen by the recent surge in studies and publications on antifungal potential. This review aims to comprehend the role and applications of endophytes as a promising source of antifungal agents and enlighten on their most common mode of action.

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来源期刊

Current Bioactive Compounds Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)

CiteScore

1.90

自引率

0.00%

发文量

112

期刊介绍： The journal aims to provide comprehensive review articles on new bioactive compounds with proven activities in various biological screenings and pharmacological models with a special emphasis on stereoeselective synthesis. The aim is to provide a valuable information source of bioactive compounds synthesized or isolated, which can be used for further development of pharmaceuticals by industry and academia. The journal should prove to be essential reading for pharmacologists, natural product chemists and medicinal chemists who wish to be kept informed and up-to-date with the most important developments on new bioactive compounds of natural or synthetic origin, including their stereoeselective synthesis.