{"title":"研究了由 3-乙酰基-4-羟基-2H-色烯-2-酮和 2-氨基恶二唑衍生物衍生的一些新型席夫碱的合成、表征和生物活性","authors":"Jadhav Rajpal L., Ubale Sanjay B.","doi":"10.32628/ijsrst52411174","DOIUrl":null,"url":null,"abstract":"A set of five novel Schiff’s bases (5a-e) incorporating coumarin-1, 3, 4-oxadiazole derivative were synthesized through condensation reaction of 3-acetyl-4-hydroxy-2H-chromen-2-one with 2-aminooxadiazole derivatives as heterocyclic aromatic amines. The novel structures of these compounds were confirmed based on their elemental analysis and spectral data. All these investigated derivatives were tested against bacterial species S. aurous, E. coli, S. typhi, B. substilis using the Agar cup method, and against fungal species A. niger, P. chrysogenum, F. moneliforme and A. flavus using poison plate method. Schiff bases incorporating coumarin and 1,3,4-oxadiazole moieties have shown notable efficacy against both bacterial and fungal strains.","PeriodicalId":14387,"journal":{"name":"International Journal of Scientific Research in Science and Technology","volume":"1359 ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The Synthesis, Characterization, and Biological Activities of Some Novel Schiff Bases Derived From 3-Acetyl-4-Hydroxy-2H-Chromen-2-One And 2-Aminooxadiazole Derivatives Have Been Investigated\",\"authors\":\"Jadhav Rajpal L., Ubale Sanjay B.\",\"doi\":\"10.32628/ijsrst52411174\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"A set of five novel Schiff’s bases (5a-e) incorporating coumarin-1, 3, 4-oxadiazole derivative were synthesized through condensation reaction of 3-acetyl-4-hydroxy-2H-chromen-2-one with 2-aminooxadiazole derivatives as heterocyclic aromatic amines. The novel structures of these compounds were confirmed based on their elemental analysis and spectral data. All these investigated derivatives were tested against bacterial species S. aurous, E. coli, S. typhi, B. substilis using the Agar cup method, and against fungal species A. niger, P. chrysogenum, F. moneliforme and A. flavus using poison plate method. Schiff bases incorporating coumarin and 1,3,4-oxadiazole moieties have shown notable efficacy against both bacterial and fungal strains.\",\"PeriodicalId\":14387,\"journal\":{\"name\":\"International Journal of Scientific Research in Science and Technology\",\"volume\":\"1359 \",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-02-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Scientific Research in Science and Technology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.32628/ijsrst52411174\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Scientific Research in Science and Technology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.32628/ijsrst52411174","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The Synthesis, Characterization, and Biological Activities of Some Novel Schiff Bases Derived From 3-Acetyl-4-Hydroxy-2H-Chromen-2-One And 2-Aminooxadiazole Derivatives Have Been Investigated
A set of five novel Schiff’s bases (5a-e) incorporating coumarin-1, 3, 4-oxadiazole derivative were synthesized through condensation reaction of 3-acetyl-4-hydroxy-2H-chromen-2-one with 2-aminooxadiazole derivatives as heterocyclic aromatic amines. The novel structures of these compounds were confirmed based on their elemental analysis and spectral data. All these investigated derivatives were tested against bacterial species S. aurous, E. coli, S. typhi, B. substilis using the Agar cup method, and against fungal species A. niger, P. chrysogenum, F. moneliforme and A. flavus using poison plate method. Schiff bases incorporating coumarin and 1,3,4-oxadiazole moieties have shown notable efficacy against both bacterial and fungal strains.
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