2017年至2021年苏门答腊岛大学医学院附属医院麻风病反应概述

Open Access Macedonian Journal of Medical Sciences Pub Date : 2024-02-13 DOI:10.3889/oamjms.2024.11837

R. Lubis, Ariyati Yosi

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引用次数: 0

摘要

背景：麻风病或称汉森氏麻风病，是一种由麻风分枝杆菌引起的慢性肉芽肿性疾病，累及皮肤和周围神经，伴有或不伴有运动障碍。麻风反应是由免疫介导的急性或亚急性炎症发作，会干扰慢性疾病的治疗，可分为三种类型：1型（RR）、2型（ENL）和卢西奥现象。研究目的：本研究旨在描述苏门答腊大学（USU）教学医院的麻风反应流行病学，并描述与麻风反应相关的因素，为今后的研究提供有价值的信息。方法：这是一项横断面分析研究，对2017-2021年棉兰H. Adam Malik医院皮肤病与性病学综合门诊和南大教育医院的患者病历进行了全面抽样调查。结果：2017-2021年，南大医学院教育医院的麻风病反应发生率为41例。大多数反应类型为2型反应（68.3%）。1型反应的危险因素为有反应史、年龄偏大、多发病损或神经受累、合并感染，而2型反应的危险因素为LL、年龄偏小、细菌指数>4+、精神紧张、合并感染。18-59岁年龄组比例最高（95.1%），男性更常见（70.7%），大多在治疗前出现（39.1%）。麻风反应的发生率为每 100 例患者中有 26 例新发病例。结论：麻风反应中比例最高的是 2 型麻风反应，发生在成人年龄组（18-59 岁）、男性和治疗前。

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Overview of Leprosy Reactions at Universitas Sumatera Utara Medical Faculty Hospitals between 2017 and 2021

BACKGROUND: Leprosy, or Morbus Hansen, is a chronic granulomatous disease caused by Mycobacterium leprae that involves the skin and peripheral nerves, with or without motor disorders. Leprosy reactions are immune-mediated acute or subacute inflammatory episodes that interfere with chronic disease and are classified into three types: type 1 (RR), type 2 (ENL), and the Lucio phenomenon. AIM: The purpose of the study is to describe the epidemiology of leprosy reactions at Universitas Sumatera Utara (USU) teaching hospitals and provide a description of factors associated with the reactions that might provide valuable information for future studies. METHODS: This is a cross-sectional analytic study with total sampling on medical records of patients in the Dermatology and Venereology Polyclinic at H. Adam Malik Hospital Medan and USU Education Hospital in 2017–2021. RESULTS: The incidence of leprosy reactions at the USU Medical Faculty Education Hospital in 2017–2021 was 41 cases. The majority of reaction types were type 2 reactions (68.3%). Risk factors for type 1 reactions were a history of reactions, being elderly, multiple lesions or nerve involvement, and co-infections, whereas the risk factors for type 2 reactions were LL, younger age, bacterial index >4+, stress, and co-infections. The highest age group proportion was 18–59 years (95.1%) and was more common in men (70.7%), which mostly appeared before treatment (39.1%). The incidence of leprosy reactions was 26 new cases per 100 patients. CONCLUSION: The highest proportion of leprosy reactions was type 2, within the adult age group (18–59 years), males, and before treatment.

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来源期刊

Open Access Macedonian Journal of Medical Sciences Medicine-Medicine (all)

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0.00%

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1225

期刊介绍： Open Access Macedonian Journal of Medical Sciences (OAMJMS) [formerly known as Macedonian Journal of Medical Sciences] is a top-tier open access medical science journal published by the ID Design 2012/DOOEL Skopje, Rajko Zhinzifov No 48, 1000 Skopje, Republic of Macedonia. OAMJMS is an international, modern, general medical journal covering all areas in the medical sciences, from basic studies to large clinical trials and cost-effectiveness analyses. We publish mostly human studies that substantially enhance our understanding of disease epidemiology, etiology, and physiology; the development of prognostic and diagnostic technologies; trials that test the efficacy of specific interventions and those that compare different treatments; and systematic reviews. We aim to promote translation of basic research into clinical investigation, and of clinical evidence into practice. We publish occasional studies in animal models when they report outstanding research findings that are highly clinically relevant. Our audience is the international medical community as well as educators, policy makers, patient advocacy groups, and interested members of the public around the world. OAMJMS is published quarterly online version. The Open Access Macedonian Journal of Medical Sciences (OAMJMS) publishes Medical Informatics, Basic Science, Clinical Science, Case Report, Brief Communication, Public Health, Public Policy, and Review Article from all fields of medicine and related fields. This journal also publishes, continuously or occasionally, the bibliographies of the members of the Society, medical history, medical publications, thesis abstracts, book reviews, reports on meetings, information on future meetings, important events and dates, and various headings which contribute to the development of the corresponding scientific field.