多囊卵巢综合征患者接受肌醇和硫辛酸治疗后的卵巢动脉多普勒测速效果

Piazze Juan, Perruzza Marta, Donfrancesco Cristina, Rizzo Giuseppe
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摘要

背景:多卵巢综合征(PCOs)是绝经前妇女最常见的内分泌和代谢疾病之一。本文是扩展报告的第二部分,介绍了基于阿法硫辛酸(ALA)/肌醇(Myoinositol)联合药物的疗法对附件参数的显著影响,并通过超声波技术进行了评估。方法:前瞻性队列试验:前瞻性队列试验。研究对象为 34 名意大利无子宫妇女,对照病例从最初的 69 名健康妇女中选出,按年龄和无子宫状态进行配对。患者在二十四个月内持续接受肌醇加ALA疗法,每天两次。超声波检查时间为月经来潮的第五天,具体安排如下:时间 0(首次评估)、时间 12(12 个月后)和时间 24(24 个月后)。结果平均年龄为 31.4 岁。在试验期间,子宫内膜宽度、卵泡数量和卵巢体积均无明显变化。相反,与卵巢动脉彩色多普勒测速波有关的参数则显示出明显的下降趋势,包括最初的数值以及 12 个月和 24 个月后的数值。结论考虑到卵巢动脉阻力的持续显著下降,我们可以假设肌醇加 ALA疗法可以阻断高雄激素对血管的影响,可能在抗氧化和抗炎途径中发挥作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Ovarian artery Doppler velocimetry effects after myoinositol and lipoic acid therapy in PCOs patients
Background: Polycistic ovary syndrome (PCOs) is one of the most common endocrine and metabolic disorders in premenopausal women. This is the second part of an extended report regarding the significant effects of the therapy based on an Alfa Lipoic Acid (ALA)/Myoinositol (Myo) combined drug on adnexal parameters, as assessed by ultrasound technique. Methods: A prospective cohort trial. Data regarded thirty four italian nulliparous women considered for the study, control cases were chosen from an initial group of sixty-nine healthy women group paired by age and nulliparous status. Patients underwent a Myoinositol plus ALA regimen twice a day in a continued fashion in a twenty four months period. Ultrasound examinations were coincident with the fifth day of menstrual period and were set as follows: Time 0 (first evaluation), Time 12 (after twelve months) and finally Time 24 (after 24 months). Results: The mean age was 31.4 years old. Results regarding any significant change in the endometrial width, number of follicles, and the ovarian volumes within the time of the trial, showed no significant changes in the intervals considered. Conversely, the parameters dealing with color Doppler velocimetry waves of the ovarian arteries showed a significant decreasing trend, considering the first values and after 12 and 24 months. Conclusions: Considering a consistent and significant decrease in ovarian arteries resistance, we may hypothesize that Inositol plus ALA therapy may block the vascular effects of hyperadrogenism, maybe playing a role in the anti oxidant and anti inflammatory pathways
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