The Synthesis and in vitro Study of 9-fluorenylmethoxycarbonyl Protected Non-Protein Amino Acids Antimicrobial Activity

Using the 9-fluorenylmethoxycarbonyl protecting group, 9-fluorenylme­thoxycarbonyl-(S)-β-(N-imidazolyl)-α-alanine protected non-protein amino acid, not described in the literature, were developed. Then 9-fluorenyl­methoxycarbonyl-(S)-α-methylphenylalanine, 9-fluorenylmethoxycarbon­yl-(S)-α-allylglycine, 9-fluorenylmethoxycarbonyl-(S)-α-propargylglycine were synthesized by the same method. It was shown, that the 9-fluorenyl­methoxycarbonyl-(S)-β-(N-imidazolyl)-α-alanine (3) inhibited the growth of Gram-negative Salmonella tуphimurium G-38 and 9-fluorenyl-methoxycar­bonyl-(S)-α-methyl-phenylalanine (4) inhibited the growth Gram-positive Bacillus subtilis 17-89 bacteria.