界面皮炎临床病理学研究

Renu Gupta, Md. Siddiqur Rahman, Sukanta Kumar Ghose, Shafwanur Rahman, Selina Sultana
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摘要

背景:界面性皮炎(ID)又称苔癣样组织反应,是一种皮肤反应,其特点是在低成本分析下,炎症浸润似乎覆盖了真皮-表皮交界处。多种炎症性皮肤病都表现出界面改变,组织学特征有明显重叠。研究目的:本研究的目的是将界面性皮炎与临床病理学联系起来。研究方法:这项横断面描述性研究于 2021 年 1 月至 2022 年 12 月在孟加拉国博古拉 TMSS 医学院皮肤病与性病科进行。研究对象包括 200 名 5 至 75 岁的患者。从临床确诊的苔藓样皮损病例中获取皮肤活组织切片,并送去进行组织学检查。然后与临床诊断结果进行比对。所有获得的数据均使用 SPSS 11.5 进行描述性统计分析。结果:在评估的 200 个病例中,最常见的 ID 类型是慢性单纯苔藓(95 例,占 47.5%),其次是扁平苔藓(LP)及其变种(84 例,占 42%)。LP样角化病(15 例,占 7.5%)、炎症性疣状表皮痣(ILVEN)2 例、苔癣及变异性苔癣(PLE-VA)2 例和 Prurigosimplex(PS)2 例发病率最低。84例(42%)扁平苔藓患者的临床病理一致,116例(58%)病理不一致。结论是在我们的调查中,最一致的组织学结果是基底膜变性,如沿真皮-表皮界面的淋巴细胞浸润。界面皮炎是指一组具有共同临床和组织学特征的疾病。因此,需要进行全面的组织学研究,以确定各种界面皮炎的不同特征。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A Clinicopathological Study on Interface Dermatitis
Background: Interface dermatitis (ID), also known as lichenoid tissue reaction, is a form of skin reaction characterized by an inflammatory infiltration that appears to cover the dermo-epidermal junction under inexpensively analysis. A wide range of inflammatory skin disorders demonstrate interface alteration with significant overlap of histological characteristics. Aim of the Study: The purpose of this study was to link interface dermatitis clinicopathologically. Methods: This cross-sectional descriptive type of study was conducted in the department of dermatology and venereology, TMSS Medical College, Bogura, Bangladesh, from January 2021 to December 2022. The study included 200 patients aged 5 to 75. Skin biopsies were obtained from clinically confirmed cases of lichenoid skin lesions and sent for histological investigation. The correlation was then performed with clinical diagnosis. All acquired data was analysed using descriptive statistics in SPSS 11.5. Results: Out of 200 cases evaluated, the most common type of ID was Lichen simplex chronicus (95, 47.5%), with Lichen planus (LP) and its variants coming in second (84, 42%). LP-like keratosis (15, 7.5%), Inflammatory verrucous epidermal nevus (ILVEN) 2 cases, Pityriasis lichenoides et varioliformisacuta (PLE-VA) 2 cases, and Prurigosimplex (PS) 2 cases were the least prevalent. Clinicopathological concordance was seen in 84 (42%) of the lichen planus patients and discordance in 116 (58%) of the cases. Conclusion: In our investigation, the most consistent histological results were basement membrane degenerations such as lymphocytic infiltrates along the dermo-epidermal interface. Interface dermatitis refers to a group of conditions that share clinical and histological characteristics. As a result, comprehensive histological studies are required to identify distinct features of various kinds of interface dermatitis.
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