薤白花序氢乙醇提取物和水提取物的酚含量和抗氧化活性

Q3 Pharmacology, Toxicology and Pharmaceutics

Research Journal of Pharmacy and Technology Pub Date : 2024-02-20 DOI:10.52711/0974-360x.2024.00140

Chahrazed Kaoudoune, Fatima Benchikh, Cherif Abdennour, Hassiba Benabdallah, Chawki Ben Souici, Ismahane Derafa, Walid Mamache, Smain Amira

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引用次数: 0

摘要

本研究旨在对薤白花的水乙醇提取物（EOH）和水提取物（AQE）的酚类物质含量和体外抗氧化能力进行定量分析。两种提取物的总酚（TPC）和类黄酮（TFC）含量均采用分光光度法测定。结果表明，EOH 和 AQE 的提取率分别为 18.30% 和 11.80%。与 AQE（TPC=9.71±0.53µg GAE/mg DW，TFC=5.68±0.90µg QE/ mg DW）相比，EOH 的 TPC（12.73±0.91µg GAE/mg DW）和 TFC（7.67±0.24µg QE/mg DW）含量更高。五种技术被用来训练抗氧化活性。EOH 提取物在 DPPH 自由基清除能力和 β-胡萝卜素漂白试验中具有较高的活性，而 AQE 提取物在金属螯合离子和还原力试验中具有较高的活性。然而，两种提取物在铜氧化还原能力方面没有不同的意义。在这两种提取自 A. sphaerocephalon L. 花的制剂中都观察到了适量的类黄酮和多酚，以及令人满意的抗氧化活性，但这种活性并不完全与酚类化合物的含量有关。

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Phenolic Content and Antioxidant Activity of Hydroethanolic and Aqueous Extracts of the Inflorescences of Allium sphaerocephalon L.

The objective of this effort is to quantify the amounts of phenolics and the in vitro antioxidant capacities of Allium sphaerocephalon L. flowers’ hydroethanolic (EOH) and aqueous (AQE) extracts. The two extracts' total phenolic (TPC) and flavonoid content (TFC) were determined spectrophotometrically. Results showed the extraction yield obtained by EOH and AQE were 18.30% and 11.80%, respectively. The EOH gave higher amounts of TPC (12.73±0.91µg GAE/mg DW) and TFC (7.67±0.24µg QE/mg DW) than AQE (TPC = 9.71±0.53µg GAE/mg DW and TFC= 5.68±0.90µg QE/ mg DW). Five techniques were used to train antioxidant activity. The EOH extract had high activity in DPPH radical scavenging capacities and β-carotene bleaching assay, while the AQE extract had high activity in metal chelating ions and reducing power assay. However, both extracts had no different significance in cupric-reducing capacity. A moderate quantity of flavonoids and polyphenols, as well as a satisfactory level of antioxidant activity, were observed in both preparations derived from the flowers of A. sphaerocephalon L., where this activity is not all fully related to the amount of phenolic compounds.

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来源期刊

Research Journal of Pharmacy and Technology Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

CiteScore

1.40

自引率

0.00%

发文量

期刊介绍： Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal, devoted to pharmaceutical sciences. The aim of RJPT is to increase the impact of pharmaceutical research both in academia and industry, with strong emphasis on quality and originality. RJPT publishes Original Research Articles, Short Communications, Review Articles in all areas of pharmaceutical sciences from the discovery of a drug up to clinical evaluation. Topics covered are: Pharmaceutics and Pharmacokinetics; Pharmaceutical chemistry including medicinal and analytical chemistry; Pharmacognosy including herbal products standardization and Phytochemistry; Pharmacology: Allied sciences including drug regulatory affairs, Pharmaceutical Marketing, Pharmaceutical Microbiology, Pharmaceutical biochemistry, Pharmaceutical Education and Hospital Pharmacy.