Thanh Minh Pham, Phuoc Minh Thanh Mai, Thi Mai Huong Le, Van Phuc Phan
{"title":"关于制备Fe₃O₄@lapatinib纳米颗粒作为靶向给药系统应用于乳腺癌治疗的研究","authors":"Thanh Minh Pham, Phuoc Minh Thanh Mai, Thi Mai Huong Le, Van Phuc Phan","doi":"10.53747/nst.v13i1.410","DOIUrl":null,"url":null,"abstract":"Systems for targeted drug delivery in the treatment of cancer using nanoparticles are currently of interest to many domestic and foreign scientists. In this work, for application as a target drug delivery system in the treatment of breast cancer Fe3O4@lapatinib nanoparticles were prepared by coprecipitation of solutions of Fe2+ and Fe3+ salts in alkaline, followed by purification in a magnetic separation system. Physicochemical properties of nanoparticles were studied and determined by XRD, TEM, DLS, HPLC, VSM, AAS and zeta potential methods. The results showed that the size of Fe3O4@lapatinib nanoparticles is in the range of 10 to 40 nm, hydrodynamic diameter is 27.4 ± 0.6 nm, saturation magnetization is 39.1 ± 3.1 emu/g, Fe content is 16.35 ± 0.97 mg/ml, lapatinib content is 8.08 ± 0.06 mg/ml, and the zeta potential is -16.2 ± 1.3 mV. Thus, the obtained Fe3O4@lapatinib nanoparticles are fully suitable for targeted drug delivery in the breast cance treatment","PeriodicalId":19445,"journal":{"name":"Nuclear Science and Technology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Study on preparation of Fe₃O₄@lapatinib nanoparticles for application as a targeted drug delivery system in the treatment of breast cancer\",\"authors\":\"Thanh Minh Pham, Phuoc Minh Thanh Mai, Thi Mai Huong Le, Van Phuc Phan\",\"doi\":\"10.53747/nst.v13i1.410\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Systems for targeted drug delivery in the treatment of cancer using nanoparticles are currently of interest to many domestic and foreign scientists. In this work, for application as a target drug delivery system in the treatment of breast cancer Fe3O4@lapatinib nanoparticles were prepared by coprecipitation of solutions of Fe2+ and Fe3+ salts in alkaline, followed by purification in a magnetic separation system. Physicochemical properties of nanoparticles were studied and determined by XRD, TEM, DLS, HPLC, VSM, AAS and zeta potential methods. The results showed that the size of Fe3O4@lapatinib nanoparticles is in the range of 10 to 40 nm, hydrodynamic diameter is 27.4 ± 0.6 nm, saturation magnetization is 39.1 ± 3.1 emu/g, Fe content is 16.35 ± 0.97 mg/ml, lapatinib content is 8.08 ± 0.06 mg/ml, and the zeta potential is -16.2 ± 1.3 mV. Thus, the obtained Fe3O4@lapatinib nanoparticles are fully suitable for targeted drug delivery in the breast cance treatment\",\"PeriodicalId\":19445,\"journal\":{\"name\":\"Nuclear Science and Technology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-02-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nuclear Science and Technology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.53747/nst.v13i1.410\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nuclear Science and Technology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.53747/nst.v13i1.410","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Study on preparation of Fe₃O₄@lapatinib nanoparticles for application as a targeted drug delivery system in the treatment of breast cancer
Systems for targeted drug delivery in the treatment of cancer using nanoparticles are currently of interest to many domestic and foreign scientists. In this work, for application as a target drug delivery system in the treatment of breast cancer Fe3O4@lapatinib nanoparticles were prepared by coprecipitation of solutions of Fe2+ and Fe3+ salts in alkaline, followed by purification in a magnetic separation system. Physicochemical properties of nanoparticles were studied and determined by XRD, TEM, DLS, HPLC, VSM, AAS and zeta potential methods. The results showed that the size of Fe3O4@lapatinib nanoparticles is in the range of 10 to 40 nm, hydrodynamic diameter is 27.4 ± 0.6 nm, saturation magnetization is 39.1 ± 3.1 emu/g, Fe content is 16.35 ± 0.97 mg/ml, lapatinib content is 8.08 ± 0.06 mg/ml, and the zeta potential is -16.2 ± 1.3 mV. Thus, the obtained Fe3O4@lapatinib nanoparticles are fully suitable for targeted drug delivery in the breast cance treatment
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