Parepalli Suresh, VP Karthik, Durai Pandian Chamundeeswari, S. Viswanathan
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Results: Saponins, tannins and flavonoids were detected in chloroform and ethanolic extract. Hydroalcoholic extract contained alkaloids along with flavonoids and saponins. Terpinoids were detected in ethanolic and hexane extracts. Hexane and chloroform extracts of this plant showed very less antioxidant properties in comparison to ethanolic and hydroalcoholic extracts. And in comparison, to ethanolic extract, hydroalcoholic extract showed good antioxidant property in a dose dependent manner. Ethanolic extract showed %inhibition of 26.60, 30.09, 32.93, 34.40, 36.70 at 10µg, 100µg, 300µg, 500µg, 1000µg/ml of concentration respectively. Hydroalcoholic extract showed % inhibition of 24.95, 35.32, 58.07, 59.44, 74.58 at 10µg, 100µg, 300µg, 500µg, 1000µg/ml concentrations respectively. Conclusion: Hydroalcoholic extract of Dicliptera cuneata Nees may be considered as potent antioxidant and may be tested for its efficacy in other in-vitro and in-vivo models.","PeriodicalId":21141,"journal":{"name":"Research Journal of Pharmacy and Technology","volume":"169 ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A Study on Evaluation of the Phytochemical Constituents and Antioxidant property in various extract preparations of Dicliptera cuneata Nees\",\"authors\":\"Parepalli Suresh, VP Karthik, Durai Pandian Chamundeeswari, S. Viswanathan\",\"doi\":\"10.52711/0974-360x.2024.00135\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background: Dicliptera cuneata Nees plant belongs to family Acanthaceae. This plant is commonly called as karunkuruntu (tamil) and pinchakusuma (telugu). This is inhabited in deciduous to moist deciduous forests. This study aimed to evaluate the phytochemical constituents and antioxidant property in various extract preparations of this plant through standard procedures. Method: Chemical test for identification of various phytochemicals (flavonoids, terpenoids, saponins, alkaloids, tannins, phenols, glycosides, steroids) in chloroform, ethanolic, alcoholic and hydroalcoholic extracts of Dicliptera cuneata Nees was evaluated using standard methods as described in previous literature. Antioxidant activity of the extracts was performed using DPPH method. Results: Saponins, tannins and flavonoids were detected in chloroform and ethanolic extract. Hydroalcoholic extract contained alkaloids along with flavonoids and saponins. Terpinoids were detected in ethanolic and hexane extracts. Hexane and chloroform extracts of this plant showed very less antioxidant properties in comparison to ethanolic and hydroalcoholic extracts. And in comparison, to ethanolic extract, hydroalcoholic extract showed good antioxidant property in a dose dependent manner. Ethanolic extract showed %inhibition of 26.60, 30.09, 32.93, 34.40, 36.70 at 10µg, 100µg, 300µg, 500µg, 1000µg/ml of concentration respectively. Hydroalcoholic extract showed % inhibition of 24.95, 35.32, 58.07, 59.44, 74.58 at 10µg, 100µg, 300µg, 500µg, 1000µg/ml concentrations respectively. Conclusion: Hydroalcoholic extract of Dicliptera cuneata Nees may be considered as potent antioxidant and may be tested for its efficacy in other in-vitro and in-vivo models.\",\"PeriodicalId\":21141,\"journal\":{\"name\":\"Research Journal of Pharmacy and Technology\",\"volume\":\"169 \",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-02-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Research Journal of Pharmacy and Technology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.52711/0974-360x.2024.00135\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"Pharmacology, Toxicology and Pharmaceutics\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Research Journal of Pharmacy and Technology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.52711/0974-360x.2024.00135","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Pharmacology, Toxicology and Pharmaceutics","Score":null,"Total":0}
引用次数: 0
摘要
背景介绍Dicliptera cuneata Nees 属于刺桐科。这种植物通常被称为 karunkuruntu(泰米尔语)和 pinchakusuma(泰卢固语)。它栖息于落叶至潮湿的落叶林中。本研究旨在通过标准程序评估该植物各种提取物制剂中的植物化学成分和抗氧化特性。方法采用以往文献中描述的标准方法,对 Dicliptera cuneata Nees 的氯仿、乙醇、酒精和水醇提取物中的各种植物化学成分(黄酮类、萜类、皂苷、生物碱、单宁、酚类、苷类、类固醇)进行化学测试鉴定。提取物的抗氧化活性采用 DPPH 法进行测定。结果如下在氯仿和乙醇提取物中检测到了皂苷、单宁和黄酮类化合物。水醇提取物中含有生物碱以及黄酮和皂苷。乙醇提取物和正己烷提取物中检测到了萜类化合物。与乙醇提取物和水醇提取物相比,这种植物的己烷提取物和氯仿提取物显示出的抗氧化特性非常低。与乙醇提取物相比,水醇提取物以剂量依赖的方式显示出良好的抗氧化性。乙醇提取物在 10µg、100µg、300µg、500µg、1000µg/ml 浓度下的抑制率分别为 26.60%、30.09%、32.93%、34.40%、36.70%。水醇提取物在 10µg、100µg、300µg、500µg、1000µg/ml 浓度下的抑制率分别为 24.95%、35.32%、58.07%、59.44%、74.58%。结论Dicliptera cuneata Nees 的水醇提取物可被视为有效的抗氧化剂,可在其他体外和体内模型中测试其功效。
A Study on Evaluation of the Phytochemical Constituents and Antioxidant property in various extract preparations of Dicliptera cuneata Nees
Background: Dicliptera cuneata Nees plant belongs to family Acanthaceae. This plant is commonly called as karunkuruntu (tamil) and pinchakusuma (telugu). This is inhabited in deciduous to moist deciduous forests. This study aimed to evaluate the phytochemical constituents and antioxidant property in various extract preparations of this plant through standard procedures. Method: Chemical test for identification of various phytochemicals (flavonoids, terpenoids, saponins, alkaloids, tannins, phenols, glycosides, steroids) in chloroform, ethanolic, alcoholic and hydroalcoholic extracts of Dicliptera cuneata Nees was evaluated using standard methods as described in previous literature. Antioxidant activity of the extracts was performed using DPPH method. Results: Saponins, tannins and flavonoids were detected in chloroform and ethanolic extract. Hydroalcoholic extract contained alkaloids along with flavonoids and saponins. Terpinoids were detected in ethanolic and hexane extracts. Hexane and chloroform extracts of this plant showed very less antioxidant properties in comparison to ethanolic and hydroalcoholic extracts. And in comparison, to ethanolic extract, hydroalcoholic extract showed good antioxidant property in a dose dependent manner. Ethanolic extract showed %inhibition of 26.60, 30.09, 32.93, 34.40, 36.70 at 10µg, 100µg, 300µg, 500µg, 1000µg/ml of concentration respectively. Hydroalcoholic extract showed % inhibition of 24.95, 35.32, 58.07, 59.44, 74.58 at 10µg, 100µg, 300µg, 500µg, 1000µg/ml concentrations respectively. Conclusion: Hydroalcoholic extract of Dicliptera cuneata Nees may be considered as potent antioxidant and may be tested for its efficacy in other in-vitro and in-vivo models.
期刊介绍:
Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal, devoted to pharmaceutical sciences. The aim of RJPT is to increase the impact of pharmaceutical research both in academia and industry, with strong emphasis on quality and originality. RJPT publishes Original Research Articles, Short Communications, Review Articles in all areas of pharmaceutical sciences from the discovery of a drug up to clinical evaluation. Topics covered are: Pharmaceutics and Pharmacokinetics; Pharmaceutical chemistry including medicinal and analytical chemistry; Pharmacognosy including herbal products standardization and Phytochemistry; Pharmacology: Allied sciences including drug regulatory affairs, Pharmaceutical Marketing, Pharmaceutical Microbiology, Pharmaceutical biochemistry, Pharmaceutical Education and Hospital Pharmacy.