利用聚合物平台技术提高抗糖尿病药物吡格列酮的溶解度

Q3 Pharmacology, Toxicology and Pharmaceutics
Nilima Navnath Khakal, Nagesh Hanmantrao Aloorkar
{"title":"利用聚合物平台技术提高抗糖尿病药物吡格列酮的溶解度","authors":"Nilima Navnath Khakal, Nagesh Hanmantrao Aloorkar","doi":"10.52711/0974-360x.2024.00134","DOIUrl":null,"url":null,"abstract":"A “drug delivery system” should be able to reduce toxicity and improve therapeutic benefits. The present investigation aimed to provide an approach for the solubility and bioavailability enhancement by a novel polymer platform Drug delivery system. Platform technology contains a polymeric system with a release modulator and can accommodate drugs with common physicochemical /therapeutic properties with minimal changes. Pioglitazone, BCS class II drug results in sub-therapeutic plasma drug levels which can cause failure in therapeutic response. When it comes to make PIO dissolved and soluble, microwave assisted ball milling technique was followed. Chitosan and neusiline US2 were used to prepare solid dispersion forming ternary complexation. Optimization of solid dispersion of ternary complexation, a “32 level full factorial design with Design Expert Software version 12” had been used. Pioglitazone–CH-neusiline systems helped in marked development of solubility of initial medicinal water, drug dissolution and drug stability. According to the “FTIR, DSC, and XRPD studies, PIO-CH-NS complexes could be prepared by microwave-assisted milling technology has formed stable crystalline in a ternary complex system. A novel polymer platform technique increases bioavailability, enhancing the therapeutic effect while reducing the toxicity of drug molecules with improving patient compliance.","PeriodicalId":21141,"journal":{"name":"Research Journal of Pharmacy and Technology","volume":"187 ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Solubility Enhancement of Antidiabetic Drug Pioglitazone by using Polymer Platform Technology\",\"authors\":\"Nilima Navnath Khakal, Nagesh Hanmantrao Aloorkar\",\"doi\":\"10.52711/0974-360x.2024.00134\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"A “drug delivery system” should be able to reduce toxicity and improve therapeutic benefits. The present investigation aimed to provide an approach for the solubility and bioavailability enhancement by a novel polymer platform Drug delivery system. Platform technology contains a polymeric system with a release modulator and can accommodate drugs with common physicochemical /therapeutic properties with minimal changes. Pioglitazone, BCS class II drug results in sub-therapeutic plasma drug levels which can cause failure in therapeutic response. When it comes to make PIO dissolved and soluble, microwave assisted ball milling technique was followed. Chitosan and neusiline US2 were used to prepare solid dispersion forming ternary complexation. Optimization of solid dispersion of ternary complexation, a “32 level full factorial design with Design Expert Software version 12” had been used. Pioglitazone–CH-neusiline systems helped in marked development of solubility of initial medicinal water, drug dissolution and drug stability. According to the “FTIR, DSC, and XRPD studies, PIO-CH-NS complexes could be prepared by microwave-assisted milling technology has formed stable crystalline in a ternary complex system. A novel polymer platform technique increases bioavailability, enhancing the therapeutic effect while reducing the toxicity of drug molecules with improving patient compliance.\",\"PeriodicalId\":21141,\"journal\":{\"name\":\"Research Journal of Pharmacy and Technology\",\"volume\":\"187 \",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-02-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Research Journal of Pharmacy and Technology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.52711/0974-360x.2024.00134\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"Pharmacology, Toxicology and Pharmaceutics\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Research Journal of Pharmacy and Technology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.52711/0974-360x.2024.00134","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Pharmacology, Toxicology and Pharmaceutics","Score":null,"Total":0}
引用次数: 0

摘要

一种 "给药系统 "应能减少毒性并提高治疗效果。本研究旨在提供一种通过新型聚合物平台给药系统提高溶解度和生物利用度的方法。该平台技术包含一个带有释放调节剂的聚合物系统,能以最小的变化容纳具有共同理化/治疗特性的药物。吡格列酮是 BCS II 类药物,其血浆药物浓度低于治疗水平,会导致治疗反应失败。为了使 PIO 溶解,我们采用了微波辅助球磨技术。壳聚糖和新西林 US2 被用来制备形成三元复合物的固体分散体。优化三元复合物的固体分散体时,采用了 "32 级全因子设计,设计专家软件版本 12"。Pioglitazone-CH-neusiline 系统有助于显著提高初始药水的溶解度、药物溶解度和药物稳定性。根据 "傅立叶变换红外光谱(FTIR)、电化学稳定性(DSC)和 XRPD 研究",通过微波辅助研磨技术制备的 PIO-CH-NS 复合物在三元复合物体系中形成了稳定的晶体。新型聚合物平台技术提高了生物利用度,增强了治疗效果,同时降低了药物分子的毒性,改善了患者的依从性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Solubility Enhancement of Antidiabetic Drug Pioglitazone by using Polymer Platform Technology
A “drug delivery system” should be able to reduce toxicity and improve therapeutic benefits. The present investigation aimed to provide an approach for the solubility and bioavailability enhancement by a novel polymer platform Drug delivery system. Platform technology contains a polymeric system with a release modulator and can accommodate drugs with common physicochemical /therapeutic properties with minimal changes. Pioglitazone, BCS class II drug results in sub-therapeutic plasma drug levels which can cause failure in therapeutic response. When it comes to make PIO dissolved and soluble, microwave assisted ball milling technique was followed. Chitosan and neusiline US2 were used to prepare solid dispersion forming ternary complexation. Optimization of solid dispersion of ternary complexation, a “32 level full factorial design with Design Expert Software version 12” had been used. Pioglitazone–CH-neusiline systems helped in marked development of solubility of initial medicinal water, drug dissolution and drug stability. According to the “FTIR, DSC, and XRPD studies, PIO-CH-NS complexes could be prepared by microwave-assisted milling technology has formed stable crystalline in a ternary complex system. A novel polymer platform technique increases bioavailability, enhancing the therapeutic effect while reducing the toxicity of drug molecules with improving patient compliance.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Research Journal of Pharmacy and Technology
Research Journal of Pharmacy and Technology Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
CiteScore
1.40
自引率
0.00%
发文量
0
期刊介绍: Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal, devoted to pharmaceutical sciences. The aim of RJPT is to increase the impact of pharmaceutical research both in academia and industry, with strong emphasis on quality and originality. RJPT publishes Original Research Articles, Short Communications, Review Articles in all areas of pharmaceutical sciences from the discovery of a drug up to clinical evaluation. Topics covered are: Pharmaceutics and Pharmacokinetics; Pharmaceutical chemistry including medicinal and analytical chemistry; Pharmacognosy including herbal products standardization and Phytochemistry; Pharmacology: Allied sciences including drug regulatory affairs, Pharmaceutical Marketing, Pharmaceutical Microbiology, Pharmaceutical biochemistry, Pharmaceutical Education and Hospital Pharmacy.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信