大鼠前额叶皮层中的 D1 类和 D2 类多巴胺受体:遗传性广泛性癫痫和社会行为缺陷的影响

Receptors Pub Date : 2024-02-20 DOI:10.3390/receptors3010004
L. Birioukova, Gilles van Luijtelaar, Inna S. Midzyanovskaya
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引用次数: 0

摘要

前额叶皮质多巴胺能系统参与癫痫和自闭症谱系障碍(ASD)等合并症的精神病理学仍有待探索。我们使用自显影技术研究了正常 Wistar 大鼠和患有全身抽搐性和/或非抽搐性癫痫的 Wistar 衍生品系大鼠前额叶皮层中的 D1 样(D1DR)和 D2 样(D2DR)受体结合密度。WAG/Rij大鼠是非惊厥失神性癫痫的模型,WAG/Rij-AGS是惊厥/非惊厥混合型癫痫的模型,而KM品系则是惊厥性癫痫合并ASD样行为表型的模型。所研究的任何癫痫病理大鼠的前额叶皮层都显示出 D1DR 和 D2DR 结合密度的显著下降;这种影响主要集中在初级和次级前扣带回皮层以及邻近区域。局部 D1DR 和 D2DR 结合密度的降低相互独立(不相关)。具有类似 ASD 表型的特定癫痫大鼠组(KM 株)的外侧前额叶皮层发生了变化:D1DR降低,而D2DR升高。因此,大鼠原核多巴胺能系统中与癫痫相关的变化被定位在内侧前额叶区域,而与 ASD 相关的变化则出现在外侧前额叶方面。研究结果表明,局部多巴胺能功能障碍可能与全身性癫痫和/或自闭症有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
D1-Like and D2-Like Dopamine Receptors in the Rat Prefrontal Cortex: Impacts of Genetic Generalized Epilepsies and Social Behavioral Deficits
The involvement of the prefrontal cortical dopaminergic system in the psychopathology of epilepsies and comorbid conditions such as autism spectrum disorder (ASD) still needs to be explored. We used autoradiography to study the D1-like (D1DR) and D2-like (D2DR) receptor binding density in the prefrontal cortex of normal Wistar rats and Wistar-derived strains with generalized convulsive and/or non-convulsive epilepsy. WAG/Rij rats served as a model for non-convulsive absence epilepsy, WAG/Rij-AGS as a model of mixed convulsive/non-convulsive form, and KM strain was a model for convulsive epilepsy comorbid with an ASD-like behavioral phenotype. The prefrontal cortex of rats with any epileptic pathology studied demonstrated profound decreases in binding densities to both D1DR and D2DR; the effects were localized in the primary and secondary anterior cingulate cortices, and adjacent regions. The local decreased D1DR and D2DR binding densities were independent of (not correlated with) each other. The particular group of epileptic rats with an ASD-like phenotype (KM strain) displayed changes in the lateral prefrontal cortex: D1DR were lowered, whereas D2DR were elevated, in the dysgranular insular cortex and adjacent regions. Thus, epilepsy-related changes in the dopaminergic system of the rat archeocortex were localized in the medial prefrontal regions, whereas ASD-related changes were seen in the lateral prefrontal aspects. The findings point to putative local dopaminergic dysfunctions, associated with generalized epilepsies and/or ASD.
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