新生儿呼吸系统病变和围产期中枢神经系统损伤时人工通气的死亡预测算法

M. G. Pukhtinskaya, V. V. Estrin
{"title":"新生儿呼吸系统病变和围产期中枢神经系统损伤时人工通气的死亡预测算法","authors":"M. G. Pukhtinskaya, V. V. Estrin","doi":"10.24884/2078-5658-2024-21-1-65-74","DOIUrl":null,"url":null,"abstract":"The objective was to predict the fatal outcome of the disease in newborns on artificial lung ventilation by means of an intelligent analysis of the immunological database.Materials and methods. The retrospective clinical study included 108 mature newborns. Upon admission to the intensive care unit, on the 3rdday and at the end of the disease, the plasma concentrations of IL-1β, IL-6, IL-8, TNF-α, G-CSF, s-Fas, FGF, NO were determined by ELISA; the relative content of CD3+CD19–, CD3–CD19+, CD3+CD4+, CD3+CD8+, CD69+, CD71+, CD95+, HLA-DR+, CD34+; CD14+, CD3–CD56+ by immunophenotyping; relative content of lymphocytes with expression of AnnexinV-FITC+PI–, AnnexinV-FITC+PI+. By the method of decision trees, the rule of predicting death was formulated.Results. The patient is predicted fatal outcome if, upon admission to intensive care, he has the relative content of lymphocytes with expression of AnnexinV-FITC+PI+ ≥ 0.95 % and plasma concentration of G-CSF ≤ 1.46 pg\\ml or G-CSF ≥ 1.46 pg\\ml and AnnexinV-FITC+PI+ ≥ 4.75 %(specificity 98.68 %; sensitivity 96.97 %; accuracy 98.68 %).Conclusion. In newborns with respiratory pathology and perinatal involvement of the central nervous system on artificial ventilation, death is determined by the high activity of T-lymphocyte apoptosis mediated by the low plasma concentration of granulocyte colony stimulating factor.","PeriodicalId":506088,"journal":{"name":"Messenger of ANESTHESIOLOGY AND RESUSCITATION","volume":"35 5","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Algorithm for predicting death in newborns with respiratory pathology and perinatal damage to the central nervous system on artificial ventilation\",\"authors\":\"M. G. Pukhtinskaya, V. V. Estrin\",\"doi\":\"10.24884/2078-5658-2024-21-1-65-74\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The objective was to predict the fatal outcome of the disease in newborns on artificial lung ventilation by means of an intelligent analysis of the immunological database.Materials and methods. The retrospective clinical study included 108 mature newborns. Upon admission to the intensive care unit, on the 3rdday and at the end of the disease, the plasma concentrations of IL-1β, IL-6, IL-8, TNF-α, G-CSF, s-Fas, FGF, NO were determined by ELISA; the relative content of CD3+CD19–, CD3–CD19+, CD3+CD4+, CD3+CD8+, CD69+, CD71+, CD95+, HLA-DR+, CD34+; CD14+, CD3–CD56+ by immunophenotyping; relative content of lymphocytes with expression of AnnexinV-FITC+PI–, AnnexinV-FITC+PI+. By the method of decision trees, the rule of predicting death was formulated.Results. The patient is predicted fatal outcome if, upon admission to intensive care, he has the relative content of lymphocytes with expression of AnnexinV-FITC+PI+ ≥ 0.95 % and plasma concentration of G-CSF ≤ 1.46 pg\\\\ml or G-CSF ≥ 1.46 pg\\\\ml and AnnexinV-FITC+PI+ ≥ 4.75 %(specificity 98.68 %; sensitivity 96.97 %; accuracy 98.68 %).Conclusion. In newborns with respiratory pathology and perinatal involvement of the central nervous system on artificial ventilation, death is determined by the high activity of T-lymphocyte apoptosis mediated by the low plasma concentration of granulocyte colony stimulating factor.\",\"PeriodicalId\":506088,\"journal\":{\"name\":\"Messenger of ANESTHESIOLOGY AND RESUSCITATION\",\"volume\":\"35 5\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-02-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Messenger of ANESTHESIOLOGY AND RESUSCITATION\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.24884/2078-5658-2024-21-1-65-74\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Messenger of ANESTHESIOLOGY AND RESUSCITATION","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.24884/2078-5658-2024-21-1-65-74","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

目的是通过对免疫学数据库进行智能分析,预测接受人工肺通气的新生儿患病后的致命结局。这项回顾性临床研究包括 108 名成熟的新生儿。在进入重症监护室时、第 3 天和疾病结束时,用 ELISA 方法测定了血浆中 IL-1β、IL-6、IL-8、TNF-α、G-CSF、s-Fas、FGF、NO 的浓度;CD3+CD19-、CD3-CD19+、CD3+CD4+、CD3+CD8+、CD69+、CD71+、CD95+、HLA-DR+、CD34+、CD14+、CD3-CD56+的相对含量;AnnexinV-FITC+PI-、AnnexinV-FITC+PI+淋巴细胞的相对含量。通过决策树的方法,制定了预测死亡的规则。如果患者在进入重症监护室时,表达AnnexinV-FITC+PI+的淋巴细胞相对含量≥0.95 %,且血浆中G-CSF浓度≤1.46 pg\ml 或G-CSF≥1.46 pg\ml 且AnnexinV-FITC+PI+≥4.75 %(特异性98.68 %;敏感性96.97 %;准确性98.68 %),则可预测其死亡结果。新生儿呼吸系统病变和围产期中枢神经系统受累并接受人工通气时,死亡是由粒细胞集落刺激因子的低血浆浓度介导的T淋巴细胞凋亡的高活性决定的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Algorithm for predicting death in newborns with respiratory pathology and perinatal damage to the central nervous system on artificial ventilation
The objective was to predict the fatal outcome of the disease in newborns on artificial lung ventilation by means of an intelligent analysis of the immunological database.Materials and methods. The retrospective clinical study included 108 mature newborns. Upon admission to the intensive care unit, on the 3rdday and at the end of the disease, the plasma concentrations of IL-1β, IL-6, IL-8, TNF-α, G-CSF, s-Fas, FGF, NO were determined by ELISA; the relative content of CD3+CD19–, CD3–CD19+, CD3+CD4+, CD3+CD8+, CD69+, CD71+, CD95+, HLA-DR+, CD34+; CD14+, CD3–CD56+ by immunophenotyping; relative content of lymphocytes with expression of AnnexinV-FITC+PI–, AnnexinV-FITC+PI+. By the method of decision trees, the rule of predicting death was formulated.Results. The patient is predicted fatal outcome if, upon admission to intensive care, he has the relative content of lymphocytes with expression of AnnexinV-FITC+PI+ ≥ 0.95 % and plasma concentration of G-CSF ≤ 1.46 pg\ml or G-CSF ≥ 1.46 pg\ml and AnnexinV-FITC+PI+ ≥ 4.75 %(specificity 98.68 %; sensitivity 96.97 %; accuracy 98.68 %).Conclusion. In newborns with respiratory pathology and perinatal involvement of the central nervous system on artificial ventilation, death is determined by the high activity of T-lymphocyte apoptosis mediated by the low plasma concentration of granulocyte colony stimulating factor.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信