关于河豚分散片的评论

Pallavi P. Ahire, Yashpal M. More, Vinay R. Kothawade, Pradnya D. Lahamge
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引用次数: 0

摘要

为提高患者的依从性和生物利用度,口崩给药系统得到了广泛应用。与传统的片剂和胶囊相比,口崩片剂(ODT)具有更高的溶解度、稳定性和患者依从性,因此在过去三十年中备受关注。本文的主要目的是回顾 ODT 技术在给药应用方面可能取得的发展。ODT 的制备方法多种多样,如大规模挤压、片剂模塑、升华、冷冻干燥和直接压缩。ODT可能是更好的选择,尤其是对胃肠道敏感的药物,以及属于儿科、老年病、卧床不起、术后或其他类别的病人,他们可能难以吞咽传统的药片和胶囊。口服含片(ODTs)是含有药物的固体剂型,放在舌头上后会迅速崩解,通常在几秒钟内就会崩解。由于生物利用度和稳定性以及患者的依从性都有所提高,因此口服溶液剂的可接受性更高。本文探讨了 ODT 开发的最新进展,包括新技术、候选药物适用性和 ODT 特征。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Review on Orodispersible Tablet
Systems for orodispersible drug delivery are widely used to increase patient compliance and bioavailability. Because of their enhanced solubility, stability profiles, and higher patient compliance compared to traditional tablets and capsules, orodispersible tablets (ODTs) have drawn a lot of attention in the last thirty years. The review of possible developments in ODT technology for drug delivery applications is the article's main goal. ODTs are prepared using a variety of methods, such as mass extrusion, tablet moulding, sublimation, freeze drying, and direct compression. ODTs may be the better option, particularly for GI-sensitive medications and for patients who fall into the paediatric, geriatric, bedridden, postoperative, or other categories and may have trouble swallowing traditional tablets and capsules. When placed on the tongue, ODTs-solid dosage forms containing medication-disintegrate quickly, often within a few seconds. ODTs have higher acceptability because of their increased bioavailability and stability, as well as patient compliance. This article examines current developments in ODT development, including new technologies, drug candidate suitability, and ODT characterization.
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