利用脂质体药物设计推进治疗:利用脂质体的潜力进行靶向给药

Rupali Singh, Sachi Sharma, Sonia Awatar, Dashain Purva, Arjun Singh
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引用次数: 0

摘要

脂质体药物设计已成为一种前景广阔的靶向给药方法。本文概述了脂质体药物设计所涉及的原则和策略,重点是优化药物稳定性、控制释放和增强治疗效果。脂质体的组成,包括脂质的选择,在决定其特性方面起着至关重要的作用。通过对脂质体的大小和表面进行修饰,可将药物有针对性地输送到特定组织或细胞。脂质体在药物封装和控制释放动力学方面具有多功能性,可在提高疗效的同时将副作用降至最低。在脂质体表面加入靶向配体可增强其对病变部位的亲和力,从而实现药物的选择性蓄积。稳定性和生产方面的考虑对于脂质体给药系统的成功转化至关重要。总之,脂质体药物设计在彻底改变给药方式以提高治疗效果方面具有巨大潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Advancing Therapeutics with Liposomal Drug Design: Harnessing the Potential of Liposomes for Targeted Drug Delivery
Liposomal drug design has emerged as a promising approach for targeted drug delivery. This article provides an overview of the principles and strategies involved in liposomal drug design, focusing on optimizing drug stability, controlled release, and enhanced therapeutic outcomes. The composition of liposomes, including the selection of lipids, plays a crucial role in determining their properties. Size and surface modifications of liposomes enable targeted drug delivery to specific tissues or cells. Liposomes offer versatility in drug encapsulation and controlled release kinetics, improving therapeutic efficacy while minimizing side effects. Incorporating targeting ligands onto liposome surfaces enhances their affinity for diseased sites, allowing for selective drug accumulation. Stability and manufacturing considerations are vital for the successful translation of liposomal drug delivery systems. Overall, liposomal drug design holds significant potential in revolutionizing drug delivery for improved treatment outcomes.
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