探索治疗骨质疏松症的再生医学策略:进展、潜力和障碍

Debojyoti Datta
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引用次数: 0

摘要

骨质疏松症是世界性的重大健康问题,尤其是老年人。目前,抗骨质吸收药物等疗法受到限制。再生医学中的干细胞治疗、基因治疗和生长因子等技术前景广阔。临床前和临床研究表明,从骨髓、脂肪组织和脐带血中提取的间充质干细胞大有可为。利用针对成骨因子(如 BMPs)的基因疗法促进骨再生是一种很有前景的方法。为了修补骨骼,生长因子、细胞因子和支架材料必不可少。要实现再生医学在治疗骨质疏松症方面的益处,需要合作和持续研究,尽管存在临床接受能力有限和监管障碍等障碍。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Exploring regenerative medicine strategies for osteoporosis treatment: Progress, potential, and hurdles
A major worldwide health problem is osteoporosis, particularly in older people. There are restrictions on current therapies, such as anti-resorptive medications. Promising techniques including stem cell treatment, gene therapy, and growth factors are available in regenerative medicine. Preclinical and clinical research indicate promise for mesenchymal stem cells derived from bone marrow, adipose tissue, and umbilical cord blood. Enhancing bone regeneration with gene therapy that targets osteogenic factors such as BMPs is a promising approach. In order to mend bones, growth factors, cytokines, and scaffold materials are essential. Realising the benefits of regenerative medicine in treating osteoporosis requires cooperation and ongoing research, despite obstacles such limited clinical acceptability and regulatory barriers.
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