与海草有关的放线菌抗菌潜力小综述

Galana Siro, Atanas Pipite
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引用次数: 0

摘要

从陆地环境到独特的海洋环境,人们一直在寻找新型治疗药物来应对抗菌药耐药性危机。目前,大多数可用药物都来自微生物代谢产物,尤其是属于放线菌细菌群的代谢产物。放线菌是存在于所有栖息地的热点生物,具有无数独特的生物合成代谢物。海草似乎是沿海环境中一个重要的生态系统,值得对其进行生物勘探,以获得新型天然产品。遗憾的是,有关与海草相关的原核生物(包括放线菌)的生物活性潜力的文献仍然有限。在这种情况下,本综述侧重于从海草植物的不同部位(即根、根茎和叶)提取的具有抗生素生产能力的放线菌。迄今为止,还没有从海草相关放线菌中提取的纯化分子进行结构阐释。本综述报告了 2012-2020 年间海草衍生放线菌的抗菌、抗真菌和杀藻活性等众多生物学特征,这些特征为知识的不断积累提供了基础,为未来的研究奠定了基础。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Mini-review on the antimicrobial potential of actinobacteria associated with seagrasses
The search for novel therapeutic agents to combat the crisis of antimicrobial resistance has spanned from terrestrial to unique, marine environments. Currently, most of the drugs available for usage are derived from microbial metabolites, especially those belonging to the bacterial group, actinobacteria. Actinobacteria are hotspot organisms that exist in all habitats with a myriad of unique biosynthetic metabolites. Seagrasses appear to be a key ecosystem within the coastal environment worth bioprospecting for novel natural products. Unfortunately, literature about the bioactive potential of their associated prokaryotes, including actinobacteria remains limited. In this context, this review focused on actinobacteria with antibiotic-producing capabilities derived from different parts of seagrass plants (i.e. roots, rhizomes, and leaves). To date, there were no purified molecules derived from seagrass-associated actinobacteria that were subjected to structure elucidation. From the underpinning of numerous biological profiles such as antibacterial, antifungal, and algicidal activities of seagrass-derived actinobacteria reported in this review during the period from 2012–2020, it provides a continual growth of knowledge accruing overtime, providing a foundation for future research.
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