Tetragonia tetragonioides 的生物活性化合物和药用潜力

O. B. Onoiko
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引用次数: 0

摘要

近年来,由于病原体对合成抗菌药物的抗药性不断增强,人们越来越多地使用在传统医学中被证明有效的植物高活性化合物。药用植物的提取物通常含有独特的物种活性成分组合,具有协同治疗效果。因此,分析栽培植物的生化成分及其潜在的生物技术应用范围是一项紧迫任务。目的总结有关旱生植物四叶草(Tetragonia tetragonioides)作为功能性食品成分和生物活性物质来源的潜力的信息,这些成分和物质可增强非特异性生物的抵抗力,有助于预防和治疗各种疾病。研究结果四季豆是一种耐盐耐热的植物,含有宝贵的营养成分和生物活性物质,以及大量维生素、矿物质和膳食纤维。高水平的抗氧化化合物,尤其是类黄酮和类胡萝卜素,有助于降低因过度氧化应激而导致退行性病变的风险。四季豆中独特的生物活性物质复合物包括 6-甲氧基黄酮醇(主要是 6-甲氧基堪非醇的衍生物)、巨黄酮及其葡萄糖苷、木质素酰胺,具有显著的抗氧化、抗炎、抗肿瘤和抗菌活性,可有效预防慢性疾病和与年龄有关的健康问题。在治疗肥胖症、高脂血症和高尿酸血症等代谢性疾病的动物模型中,四氢木质素的功效已得到证实。结论。四叶棠含有生物活性化合物(主要是 6-甲氧基黄酮醇)的特殊复合物,可能是获得治疗和预防各种慢性疾病和代谢紊乱的有效药物的一种有前途的原料。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
BIOACTIVE COMPOUNDS AND PHARMACOGNOSTIC POTENTIAL OF Tetragonia tetragonioides
In the recent years, due to the increasing resistance of pathogens to synthetic antimicrobial drugs, the use of highly active compounds from plants, which have proven their effectiveness in traditional medicine practices, is increased. Extracts of medicinal plants often contain a unique species ‒ specific combination of active ingredients that have a synergistic therapeutic effect. Therefore, the analysis of the biochemical composition of cultivated plants and the range of their potential biotechnological application is an urgent task. Aim. To summarize the information on the potential of the xerophytic plant Tetragonia tetragonioides as a source of functional food ingredients and biologically active substances that increase nonspecific organism resistance and contribute to the prevention and treatment of various diseases. Results. T. tetragonioides is a salt-tolerant and heat-resistant plant containing valuable nutrients and biologically active substances, a significant amount of vitamins, minerals, and dietary fibers. The high level of antioxidant compounds, especially flavonoids and carotenoids, helps to reduce the risk of degenerative pathologies developing associated with excessive oxidative stress. The unique complex of biologically active substances in T. tetragonioides, which includes 6-methoxyflavonols, predominantly derivatives of 6-methoxykaempferol, as well as megastigmanes and their glucosides, lignanamide, provides significant antioxidant, anti-inflammatory, antitumor, and antimicrobial activity and may be beneficial for the prevention of chronic diseases and age-related health problems. The effectiveness of T. tetragonioides has been demonstrated in animal models in the treatment of metabolic disorders such as obesity, hyperlipidemia, and hyperuricemia. Conclusions. T. tetragonioides, containing a specific complex of biologically active compounds, primarily 6-methoxyflavonols, may be a promising raw material for obtaining effective medications for the treatment and prevention of various chronic diseases and metabolic disorders.
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