{"title":"从南美白对虾(Litopenaeus vannamei)贝壳中提取的虾青素对肝毒性的评估","authors":"Niracha Yanyium, Wanida Sukketsiri, Pennapa Chonpathompikunlert, W. Klaypradit, Jirawat Saetan, Sebastien Marais, Supita Tanasawet","doi":"10.17576/jsm-2024-5302-01","DOIUrl":null,"url":null,"abstract":"Recent advances in astaxanthin encapsulation have been reported, but hepatotoxic effect remains unclear. The present investigation therefore aimed to examine the effects of encapsulated astaxanthin from white shrimp shells (Litopenaeus vannamei) on liver toxicity. Wistar rats were divided into 6 groups as control (C), and receiving vitamin E (VE), astaxanthin commercial (AC), astaxanthin extracted from white shrimp shells (AE), astaxanthin encapsulation into powder form (AP), and blank powder (BP). The evaluation of liver in response to astaxanthin administration was then assessed in terms of biochemical parameters and histopathological features. Liver enzymes, aspartate aminotransferase (AST) and alanine aminotransferase (ALT), showed no significant differences among all groups of treatment. Histopathological study showed no abnormal changes on liver tissue including hepatic inflammation. Our data demonstrated that astaxanthin encapsulation did not increase the expression of NF-ҡB nuclear translocation and CYP2E1 in comparison with the control group. Additionally, in this study, the consumption of astaxanthin and vitamin E resulted in a reduction in the oxidative stress index (OSI), while the levels of antioxidant enzymes, including glutathione peroxidase (GPx) and superoxide dismutase (SOD), were significantly increased compared to the control group. Our data suggested that astaxanthin encapsulation does not cause hepatic toxicity, contributing useful information in the applications of astaxanthin encapsulation technology.","PeriodicalId":21366,"journal":{"name":"Sains Malaysiana","volume":null,"pages":null},"PeriodicalIF":0.7000,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Evaluation of Encapsulated Astaxanthin from White Shrimp Shells (Litopenaeus vannamei) on Hepatotoxicity\",\"authors\":\"Niracha Yanyium, Wanida Sukketsiri, Pennapa Chonpathompikunlert, W. Klaypradit, Jirawat Saetan, Sebastien Marais, Supita Tanasawet\",\"doi\":\"10.17576/jsm-2024-5302-01\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Recent advances in astaxanthin encapsulation have been reported, but hepatotoxic effect remains unclear. The present investigation therefore aimed to examine the effects of encapsulated astaxanthin from white shrimp shells (Litopenaeus vannamei) on liver toxicity. Wistar rats were divided into 6 groups as control (C), and receiving vitamin E (VE), astaxanthin commercial (AC), astaxanthin extracted from white shrimp shells (AE), astaxanthin encapsulation into powder form (AP), and blank powder (BP). The evaluation of liver in response to astaxanthin administration was then assessed in terms of biochemical parameters and histopathological features. Liver enzymes, aspartate aminotransferase (AST) and alanine aminotransferase (ALT), showed no significant differences among all groups of treatment. Histopathological study showed no abnormal changes on liver tissue including hepatic inflammation. Our data demonstrated that astaxanthin encapsulation did not increase the expression of NF-ҡB nuclear translocation and CYP2E1 in comparison with the control group. Additionally, in this study, the consumption of astaxanthin and vitamin E resulted in a reduction in the oxidative stress index (OSI), while the levels of antioxidant enzymes, including glutathione peroxidase (GPx) and superoxide dismutase (SOD), were significantly increased compared to the control group. Our data suggested that astaxanthin encapsulation does not cause hepatic toxicity, contributing useful information in the applications of astaxanthin encapsulation technology.\",\"PeriodicalId\":21366,\"journal\":{\"name\":\"Sains Malaysiana\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.7000,\"publicationDate\":\"2024-02-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Sains Malaysiana\",\"FirstCategoryId\":\"103\",\"ListUrlMain\":\"https://doi.org/10.17576/jsm-2024-5302-01\",\"RegionNum\":4,\"RegionCategory\":\"综合性期刊\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"MULTIDISCIPLINARY SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Sains Malaysiana","FirstCategoryId":"103","ListUrlMain":"https://doi.org/10.17576/jsm-2024-5302-01","RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MULTIDISCIPLINARY SCIENCES","Score":null,"Total":0}
引用次数: 0
摘要
最近有报道称虾青素封装技术取得了进展,但其肝毒性作用仍不明确。因此,本研究旨在探讨从白虾壳(Litopenaeus vannamei)中提取的虾青素对肝脏毒性的影响。将Wistar大鼠分为6组,分别为对照组(C)、维生素E组(VE)、虾青素商品组(AC)、从白虾壳中提取的虾青素组(AE)、虾青素胶囊粉末组(AP)和空白粉末组(BP)。然后从生化参数和组织病理学特征方面评估肝脏对服用虾青素的反应。肝酶、天门冬氨酸氨基转移酶(AST)和丙氨酸氨基转移酶(ALT)在各组治疗中无明显差异。组织病理学研究显示,肝脏组织没有异常变化,包括肝脏炎症。我们的数据表明,与对照组相比,虾青素封装不会增加 NF-ҡB 核转位和 CYP2E1 的表达。此外,在本研究中,与对照组相比,服用虾青素和维生素 E 可降低氧化应激指数(OSI),而谷胱甘肽过氧化物酶(GPx)和超氧化物歧化酶(SOD)等抗氧化酶的水平则显著提高。我们的数据表明,虾青素封装不会引起肝毒性,这为虾青素封装技术的应用提供了有用的信息。
Evaluation of Encapsulated Astaxanthin from White Shrimp Shells (Litopenaeus vannamei) on Hepatotoxicity
Recent advances in astaxanthin encapsulation have been reported, but hepatotoxic effect remains unclear. The present investigation therefore aimed to examine the effects of encapsulated astaxanthin from white shrimp shells (Litopenaeus vannamei) on liver toxicity. Wistar rats were divided into 6 groups as control (C), and receiving vitamin E (VE), astaxanthin commercial (AC), astaxanthin extracted from white shrimp shells (AE), astaxanthin encapsulation into powder form (AP), and blank powder (BP). The evaluation of liver in response to astaxanthin administration was then assessed in terms of biochemical parameters and histopathological features. Liver enzymes, aspartate aminotransferase (AST) and alanine aminotransferase (ALT), showed no significant differences among all groups of treatment. Histopathological study showed no abnormal changes on liver tissue including hepatic inflammation. Our data demonstrated that astaxanthin encapsulation did not increase the expression of NF-ҡB nuclear translocation and CYP2E1 in comparison with the control group. Additionally, in this study, the consumption of astaxanthin and vitamin E resulted in a reduction in the oxidative stress index (OSI), while the levels of antioxidant enzymes, including glutathione peroxidase (GPx) and superoxide dismutase (SOD), were significantly increased compared to the control group. Our data suggested that astaxanthin encapsulation does not cause hepatic toxicity, contributing useful information in the applications of astaxanthin encapsulation technology.
期刊介绍:
Sains Malaysiana is a refereed journal committed to the advancement of scholarly knowledge and research findings of the several branches of science and technology. It contains articles on Earth Sciences, Health Sciences, Life Sciences, Mathematical Sciences and Physical Sciences. The journal publishes articles, reviews, and research notes whose content and approach are of interest to a wide range of scholars. Sains Malaysiana is published by the UKM Press an its autonomous Editorial Board are drawn from the Faculty of Science and Technology, Universiti Kebangsaan Malaysia. In addition, distinguished scholars from local and foreign universities are appointed to serve as advisory board members and referees.